The number of studies investigating the human gastrointestinal tract using various single-cell profiling methods has increased substantially in the past few years. Although this increase provides a unique opportunity for the generation of the first comprehensive Human Gut Cell Atlas (HGCA), there remains...
A Roadmap for the Human Gut Cell Atlas Article 31 May 2023 Main Intestinal tract physiology relies on the integrated contribution of multiple cell lineages, the relative abundance and cell networking of which fluctuate from embryonic development to adulthood. Further complexity is added because the in...
Methods: We describe a conceptual coordinate model for the Gut Cell Atlas (small and large intestines). Here, we focus on a Gut Linear Model (1-dimensional representation based on the centreline of the gut) that represents the location semantics as typically used by clinicians and pathologists ...
Areferencemapforfunction •Foundational,fundamental knowledge •Functionofgeneticvariants •Heterogeneityindisease •Eventuallycharacterizein individualpatients TheHumanCellAtlasProject How?Aunifiedproject •Pilotprojectincomplementary systems(e.g.,blood,gut,liver) •Consortiumwithexpert communities •...
The development of single-cell and spatial transcriptomics methods was instrumental in the conception of the Human Cell Atlas initiative, which aims to generate an integrated map of all cells across the human body. These technology advances are bringing increasing depth and resolution to maps of huma...
DevCell_GutAtlas This is repository for data preprocessing and analysis of the human gut single-cell data performed by me and published in https://pubmed.ncbi.nlm.nih.gov/33290721/ Abstract Human gut development requires the orchestrated interaction of various differentiating cell types. Here we ...
Studying tissue composition and function in non-human primates (NHPs) is crucial to understand the nature of our own species. Here we present a large-scale cell transcriptomic atlas that encompasses over 1 million cells from 45 tissues of the adult
The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human Cell Atlas, aims to create a comprehensive reference map of cells during development. This will be critical to understanding normal organogenesis, the effect of mutations, environmental factors and infectious agents on ...
To fill these important knowledge gaps, we perform single-cell RNA sequencing on two-day old schistosomula of. We identify likely gene expression profiles for muscle, nervous system, tegument, oesophageal gland, parenchymal/primordial gut cells, and stem cells. In addition, we validate cell ...
However, accounting for the asynchronous nature of responses, we defined a time-adjusted signature that predicted antibody responses across vaccines. These results provide a transcriptional atlas of immunity to vaccination and define a common, time-adjusted signature of antibody responses....