It covers a broad range of topics from gene structure and organization to genetic epidemiology and ethical, legal, and social issues. Human Genetics offers fast editorial turnaround times and an efficient publication process. Authors have the choice to publish using either the traditional publishing...
Researchers have made dramatic inroads into the study of polygenic and other complex human diseases, due in large part to knowledge of the human genome sequence, the generation of widespread markers of genetic variation, and the development of new technologies that allow investigators to associate ...
Testosterone supplementation is commonly used for its effects on sexual function, bone health and body composition, yet its effects on disease outcomes are unknown. To better understand this, we identified genetic determinants of testosterone levels and
Alternative splicing of pre-mRNAs provides an additional mechanism whereby genetic variation can create functional diversity across human genomes. Rare mutations and common variants that influence pre-mRNA splicing have been linked to a broad range of human diseases [15,16,17]. The effects of genetic...
Development of new drugs is of high interest for the field of cardiac and cardiovascular diseases, which are a dominant cause of death worldwide. Before be
Midic U, Oldfield CJ, Dunker AK, Obradovic Z, Uversky VN: Protein disorder in the human diseasome: Unfoldomics of human genetic diseases. BMC Genomics. 2009, 10 (Suppl 1): S12- PubMed Central PubMed Google Scholar Goh KI, Cusick ME, Valle D, Childs B, Vidal M, Barabasi AL: The ...
The genetic background of world population is unlikely changed over the last several decades. The increasing incidence of yCRC may be attributed to changing environmental and lifestyle factors. Among environmental factors, the gut microbiome—the microbial ecosystem residing primarily in the large ...
Lu believed that CRISPR-Cas9 technology has the potential to revolutionize the treatment of blood diseases, tumors and other genetic diseases. The mortality rate of lung cancer patients is high. "This is why we chose cancer patients for the initial trial. Should the approach prove safe, we will...
Multi-trait loci have been linked with several age-related diseases, suggesting shared ageing influences. Mutations that drive accelerated ageing in prototypical progeria syndromes in humans point to an important role for genome maintenance and stability. Together, these different strands of genetic ...
diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated...