HumansDiabetes Mellitus, Type 2Linkage DisequilibriumGenome, HumanGenetic Predisposition to DiseasePolymorphism, Single NucleotideThe article evaluates the genome-wide-association (GWA) studies of common diseases which aim to examine the variation in human genome. It states that GWA studies rely on ...
Most genetic diseases are the direct result of a mutation in one gene. However, one of the most difficult problems ahead is to further elucidate how genes contribute to diseases that have a complex pattern of inheritance, such as in the cases of diabetes, asthma, cancer, and mental illness....
The Rarest And Most Gruesome Genetic Diseases Known To Science What Happens When You Donate Your Body to Science Interesting Facts You Didn't Know About Yawning Doctors Reveal Warning Signs You Shouldn't Overlook Rare Genetic Features That You Probably Don't Have ...
Advances in genetic mapping of human diseases have led to the identification of single locus susceptibility for several common disorders. There have been a number of reports of linkage for the psychiatric disorders manic-depressive illness and schizophrenia, but none of these linkage reports is unconte...
Hematological traits can be useful prognostic parameters for several diseases and the overall health of individuals. PLT volume has been proposed as an independent predictor of morbidity and mortality for cardiovascular diseases (CAD).3 Therefore, the elucidation of the genetic components of an ...
OBJECTIVE: To search for genetic association between microsatellite marker loci and sibling pairs with nodal osteoarthritis (NOA). METHODS: Using the affec... GD Wright,AE Hughes,M Regan,... - 《Annals of the Rheumatic Diseases》 被引量: 726发表: 1996年 Endophenotypes in the Genetic Analyses ...
Finally, population genetic methods, including searching for genes under selection, may provide clues to the location of the genes for common disease and complex traits.doi:10.1203/01.PDR.0000159574.98964.87HirschhornJoel NPediatric ResearchHirschhorn JN: Genetic approaches to studying common diseases and...
This is translated to an expanded stretch of glutamine amino acids in the huntingtin protein (HTT) and this mutant protein is the main cause of neuropathology in HD. While extensive research has been done since 1993, when the genetic cause of the disease was discovered [1], there is still ...
individuals because loss ofgene functionsleads to diseases such ascystic fibrosisandmuscular dystrophy. The findings will allow researchers to better pinpoint new disease-causingmutationsby helping them differentiate between frequently occurring but harmless genetic variants and rare dangerous ones, the ...
et al. An atlas of genetic correlations across human diseases and traits. Nat. Genet. 47, 1236–1241 (2015). CAS PubMed PubMed Central Google Scholar Okbay, A. et al. Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide...