DNA methylation plays an important role in epigenetic signalling, having an impact on gene regulation, chromatin structure, development and disease. Here, we review the structures and functions of the mammalian DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b, including their domain structures, ...
DNA wraps around the histone octamer to form nucleosomes1, the repeating unit of chromatin, which create barriers for accessing genetic information. Snf2-like chromatin remodellers couple the energy of ATP binding and hydrolysis to reposition and recompo
During BMP-driven hPGCLC specification and differentiation, hPGCLCs and their progeny downregulated de novo DNA methyltransferases (DNMTs) (Fig.2aand Extended Data Fig.9i). The genome-wide CpA methylation, a readout for de novo DNMT activity28, was reduced in c32 cells cultured with BMP2 comp...
We chose 28 genes (Tables2and3) associated with the 28 candidate DMRs for analysis of allele-specific expression. Three to four exonic SNPs per gene were analyzed in 28 paired placental DNA and RNA samples. Two genes (DNMT1andAIM1) showed allele-specific expression. The monoallelic expression...
Barau J, Teissandier A, Zamudio N, Roy S, Nalesso V, Hérault Y, Guillou F, Bourc’his D (2016) The DNA methyltransferase DNMT3C protects male germ cells from transposon activity. Science 354:909–912 Article CAS PubMed Google Scholar Bilovocky NA, Romito-DiGiacomo RR, Murcia CL, ...
A genome-scale map of DNA methylation turnover identifies site-specific dependencies of DNMT and TET activity ArticleOpen access29 May 2020 Nature of epigenetic aging from a single-cell perspective Article09 May 2024 Main The fates of individual human cells in vivo are difficult to reconstruct. In...
Then we determined the function of ERα in regulation of DNMT1 using luciferase report gene system. Our work demonstrated that ERα could upregulate DNMT1 expression by directly binding to the DNMT1 promoter region in MFC-7(ER+)/PTX cells....
dnmt1 mRNA is undetectable in growth-arrested ... N Detich,S Ramchandani,M Szyf - 《Journal of Biological Chemistry》 被引量: 346发表: 2001年 Characterization of the promoter region and 3' end of the human insulin receptor gene. The insulin receptor is an essential protein present on the ...
ativeregulationofthereelingeneinvolvesmethylation-depen- dentrecruitmentofDNMT1,MeCP2,andcertainhistone deacetylases,whichmostlikelyreducetheactivityofthepro- moterbyshiftingthesurroundingchromatinintoamorecom- pactstate. Itisnowwellestablishedthatdisruptionofepigenetic ...
in CD8 + TEMand TEMRAsubsets but more highly expressed in naïve or TCMcells (Fig.2f) with individual genes plotted and colored according to cluster membership (Fig.2g). These were enriched for DNA methyltransferases such as DNMT3A or pathways related to T-cell differentiation, ...