DNA methylation plays an important role in epigenetic signalling, having an impact on gene regulation, chromatin structure, development and disease. Here, we review the structures and functions of the mammalian DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b, including their domain structures, ...
Based on the strong conservation of catalytic DNA methyltransferase domains we have used a homology modeling approach to determine the three-dimensional structure of the DNMT1 catalytic domain. Our results suggest an overall structural conservation with other DNA methyltransferases but also indicate local ...
DNA wraps around the histone octamer to form nucleosomes1, the repeating unit of chromatin, which create barriers for accessing genetic information. Snf2-like chromatin remodellers couple the energy of ATP binding and hydrolysis to reposition and recompo
We chose 28 genes (Tables2and3) associated with the 28 candidate DMRs for analysis of allele-specific expression. Three to four exonic SNPs per gene were analyzed in 28 paired placental DNA and RNA samples. Two genes (DNMT1andAIM1) showed allele-specific expression. The monoallelic expression...
(A) Relative expression of the naïve hPSC markers DPPA3, DNMT3L, KHDC1L, TFCP2L1, and KLF17 in naïve (HENSM) and primed hPSCs and during 5 days in TI medium, measured by RT-PCR. Student’s t test, ∗p < 0.05. n = 3 independent experiments. (B) Conversion kinetics of ...
Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA. Nucleic Acids Res. 29: 439-448... A Dong,JA Yoder,X Zhang,... - 《Nucleic Acids Research》 被引量: 544发表: 0年 MTA Is an Arabidopsis Messenger RNA Adenosine Methylase...
(Extended Data Figs.7band9j). Furthermore, hPGCLCs and their progeny downregulatedUHRF1, an essential co-factor for maintenance DNMT29,30, and with BMP2, UHRF1 partially translocated to the cytoplasm (Fig.2aand Extended Data Fig.9i,k). Compared with c32 cells without BMP2 (about 63%)...
Structure of DNMT1-DNA Complex Reveals a Role for Autoinhibition in Maintenance DNA Methylation Maintenance of genomic methylation patterns is mediated primarily by DNA methyltransferase-1 (DNMT1). We have solved structures of mouse and human DNMT1 co... J Song,O Rechkoblit,TH Bestor,... - ...
Gene NametRNA aspartic acid methyltransferase 1 Gene SymbolTRDMT1 SynonymsDMNT2; DNMT2; PUMET; RNMT1; MHSAIIP OrganismHuman Gene ID1787 UniProt IDO14717 Main Accession No.NM_004412 Other Accession No.NM_004412, NM_176081, NM_176083, NM_176084, NM_176085, NM_176086, NM_001321006, NM_00132...
ativeregulationofthereelingeneinvolvesmethylation-depen- dentrecruitmentofDNMT1,MeCP2,andcertainhistone deacetylases,whichmostlikelyreducetheactivityofthepro- moterbyshiftingthesurroundingchromatinintoamorecom- pactstate. Itisnowwellestablishedthatdisruptionofepigenetic ...