Dnmt1, the principal DNA methyltransferase in mammalian cells, is a large and a highly dynamic enzyme with multiple regulatory features that can control DNA methylation in cells. This chapter highlights how insights into Dnmt1 structure and function can advance our understanding of DNA methylation in...
参考: 1.Jurkowska R Z , Jurkowski T P , Jeltsch A . Structure and function of mammalian DNA methyltransferases.[J]. Chembiochem, 2011, 42(19):no-no. 2.谢天立. DNMT抑制剂选择性机制的探究及DNMT1抑制剂的发现[D]....
本发明涉及药化领域,特别是涉及DNMT1抑制剂在制备用于内耳毛细胞和听神经损伤保护和/或治疗听力损伤的药物中的用途。本发明提供DNMT1抑制剂在制备药物或试剂盒中的用途,所述药物或试剂盒用于:治疗听力损伤;和/或,调节细胞的氧化应激水平。本发明提供了DNMT1抑制剂在治疗听力损伤、或调节细胞的氧化应激水平中用途,证实...
In particular, the structure and function of the rather large TS domain with its multiple roles and interactions remain to be clarified. In this study, we elucidate the complex interplay between UHRF1 and DNMT1. While we could confirm the general role of UHRF1 in recruiting DNMT1 to ...
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Structure and function of mammalian DNA methyltransferases Chembiochem, 12 (2011), pp. 206-222 CrossrefView in ScopusGoogle Scholar 6. W. Reik Stability and flexibility of epigenetic gene regulation in mammalian development Nature, 447 (2007), pp. 425-432 CrossrefView in ScopusGoogle Scholar 7....
Different Binding Properties and Function of CXXC Zinc Finger Domains in Dnmt1 and Tet1 Several mammalian proteins involved in chromatin and DNA modification contain CXXC zinc finger domains. We compared the structure and function of the CXXC ... C Frauer,A Rottach,D Meilinger,... - 《Plos...
DNA甲基化基因DNMT1的研究进展
In particular, the structure and function of the rather large TS domain with its multiple roles and interactions remain to be clarified. In this study, we elucidate the complex interplay be- tween UHRF1 and DNMT1. While we could confirm the general role of UHRF1 in recruiting DNMT1 to ...
We present an... Ido,Amit,Manuel,... - 《Science》 被引量: 951发表: 2009年 Structure and function of mammalian DNA methyltransferases. Review: 214 refs. RZ Jurkowska,TP Jurkowski,A Jeltsch - 《Chembiochem》 被引量: 806发表: 2011年 加载更多...