Human Immune Cell Marker Guide VIEW INTERACTIVE PATHWAY The immune system can identify and eliminate cancer cells through both innate and adaptive mechanisms; however, such antitumor responses can be inhibited by the microenvironment through a process known as immunosuppression. Cancer immunotherapy aims ...
Furthermore, we noticed that in vitro differentiated CD14−CD1c+cDC2-like cells were heterogeneous for the expression of the mannose receptor CD206 (Fig.2a). Circulating blood cDC2s do not generally express CD206 (Supplementary Fig.3c), whereas CD206 is a marker of skin and migratory cDC219...
In proliferative glomerulonephritis numerous CD68 positive (pan monocyte, macrophage and dendritic marker) cells were found in both glomeruli and the tubulointerstitial space, however, a myeloid dendritic cell marker (DC-SIGN) was identified only in the tubulointerstitium. A significant number of ...
Lymphoid tissue and plasmacytoid dendritic cells and macrophages do not share a common macrophage–dendritic cell-restricted progenitor. Immunity 41, 104–115 (2014). Article CAS PubMed Google Scholar Liu, Z. et al. Fate mapping via Ms4a3-expression history traces monocyte-derived cells. Cell ...
(a maturation marker) is also analyzed to ensure depletion of these cell types. Cell Features: Dendritic Cells are derived from monocytes cultured with interleukin 4 and granulocyte-monocyte colony stimulating factor. Dendritic Cells are extensively tested for quality and optimal performance. AcceGen ...
An equivalent population in mice has been shown to be heterogeneous and contain functionally distinct monocyte-related and conventional dendritic cell-related subpopulations. We aimed to examine whether analogous diversity exists in human beings using the conserved conventional dendritic cell marker, B and...
The Class II MHC genes are mainly within a single cluster, Cluster 89 (GO:0042613, MHC class II protein complex, P < 8.72×10-16), and all of the unannotated probes within this cluster also map to MHCII but there is no association with any other marker or putative antigen uptake ...
Immunoreactivity to HERV Gag and Env proteins was uniquely co-localized in hematopoietic cells expressing the C-type lectin receptor CLEC4C (CD303/BDCA2), the co-stimulatory marker CD86 and the class II major histocompatibility complex HLA-DR, consistent with plasmacytoid dendritic cells (pDCs). ...
Dimensionality reduction and Leiden clustering (resolution 0.3–1.5) was carried out and cell lineages were annotated on the basis of algorithmically defined marker gene expression for each cluster (sc.tl.rank_genes_groups, method=‘wilcoxon’). Cell lineages were then subclustered and batch ...
(Fig.3C). Interestingly, the HIV binding CLR DC-SIGN, previously thought to be a DC marker and shown to be involved in capture of HIV and transfer to T cells11,31,32,33,44,45,46,47, was not expressed by any ex vivo DC subsets or ex vivo CD14+CD1c+MDDCs (although gene ...