For example, CTCF binding sites located cis to the ATXN7 gene can regulate CAG hyper- instability at that locus.31,32 We hypothesize that genetic cis-elements present in different HTT haplogroups may be regulating CAG instability at the HTT locus. Further experiments are clearly needed to ...
Interestingly, the transcription factor CCTC-binding factor (CTCF), previously shown to interact with YB-1, interferes with the ability of the VNTR to support YB-1-directed reporter gene expression. In addition, CTCF blocks the binding of YB-1 to its DNA recognition sequences in vitro, thus...