同时,HLA-DR、CD80、CD86 等典型巨噬细胞相关分子水平显著上升,这表明 HTLV-1 感染细胞可诱导单核细胞向巨噬细胞分化。 THP-1 细胞共培养后表达高水平促炎基因:研究发现,共培养后的 THP-1 细胞中,促炎细胞因子 TNF-α、IL-6 和 IL-1β 的 mRNA 水平上调,培养上清中这些细胞因子的浓度也增加。此外,与 M1...
Strongyloides antigen-specific IL-5 responses were reduced in strongyloidiasis/HTLV-1 coinfected patients (5.0 vs. 187.5 pg/ml, p = 0.03, Mann-Whitney test). Reduced IL-5 responses and eosinophil counts were inversely correlated to the number of CD4+CD25+FoxP3+ cells. Conclusions: Regulatory...
MT2 derived exosomes significantly enhanced the expression of CXCL10 mRNA, but not IL-6 and CCL5, in RASF activated by IFN-gamma. Therefore, we hypothesized that exosomes play the role of ligand for pattern recognition receptors. IFN-gamma increased the expression of RIG-I protein in RASF in...
ADF/3B6-IL-1/Thioredoxin:Produced by both HTLV-1 and EBV-transformed lymphocytes/possible role as an autocrine growth factor and a competence factor. It activates the signal pathway of Ca2+/lipid-dependent PKCADF/3B6-IL-1/Thioredoxin:Produced by both HTLV-1 and EBV-transformed lymphocytes/poss...
IL-5 responses to larval Strongyloides stercoralis antigens are decreased in patients with strongyloidiasis and HTLV-1 co-infection (n = 13) compared to HTLV-1 negative subjects with strongylo...
IL-2 immunotherapy in chronically SIV-infected Rhesus Macaques. Virol J. 2012; 9 :1–15. doi: 10.1186/1743-422X-9-1. [ Cross Ref ]Diamantopoulos PT, Michael M. Benopoulou O. Bazanis E. Tzeletas G, Meletis J, Vayopoulos G, Viniou NA: Antiretroviral activity of 5-azacytidine ...
: PCR Western Blot HTLV - 1 T - 1Jung Back KimKeum Jung KimSi Young KimHwi Joong YoonKyung Sam ChoWoo In LeeJin Tae SuhJu Hee LeeSeok Il HongThomas P Loughran대한내과학회
Increased levels of IL-6 and TNF with reduced levels of CXCL10/IP10 and CCL5/RANTES were observed in co-infected pHAM(+) as compared to mono-infected pHAM(-). HAM(+) patients revealed an increase in CXCL8/IL-8, CCL2/MCP-1, CXCL-10/IP-10, TNF and a decrease in IL-2 as ...
Here, IL-2-dependent and -independent events were analysed in a human T cell line immortalized by Tax. These studies show that, of the signaling pathways evaluated, only STAT5 remains dependent. Microarray analyses revealed several genes, including il-5, il-9 and il-13, are uniquely up...
(2002). Involvement of IL-2/IL-2R system activation by parasite antigen in polyclonal expansion of CD4(+)25(+) HTLV-1- infected T-cells in human carriers of both HTLV-1 and S. stercoralis. Oncogene, 21: 2466-2475. doi:10.1038/ sj.onc.1205329 PMID:11971181...