2021年12月,来自熊本大学等研究机构合作在The Journal of Clinical Investigation发表了“HTLV-1 infection promotes excessive T cell activation and transformation into adult T cell leukemia/lymphoma”的研究论文。该工作利用单细胞转录组和 TCR 测序等技术,证明了人类I型 T 细胞白血病病毒(HTLV-1)可激活 naive T...
2021年12月,来自熊本大学等研究机构合作在The Journal of Clinical Investigation发表了“HTLV-1 infection promotes excessive T cell activation and transformation into adult T cell leukemia/lymphoma”的研究论文。该工作利用单细胞转录组和 TCR 测序等技术,证明了人类I型 T 细胞白血病病毒(HTLV-1)可激活 naive T...
The early molecular events induced by HTLV-1 infection as well as the role of various viral genes in the induction of leukemia remain unclear, predominantly due to the lack of an animal model that recapitulates ATLL development. We have previously demonstrated that HTLV-1 is capable of ...
To further investigate the prevalence of HTLV-1 in our center and verify our hypothesis of HTLV-1 infection and aGVHD process, an independent cohort of 400 patients, including liver surgery patients, recipients, and donors of liver transplants (TableS2), were recruited from January 2021 to June...
Dr Taylor: The session we have just had is really a first in one sense, because we are talking about the elimination of HTLV-1, the human T-lymphotropic virus type 1, sometimes called human T-cell leukemia virus. We h...
Dr Taylor: The session we have just had is really a first in one sense, because we are talking about the elimination of HTLV-1, the human T-lymphotropic virus type 1, sometimes called human T-cell leukemia virus. We have been looking after patients with this infection and the consequences...
Association between HTLV-1 infection and adverse health outcomes: a systematic review and meta-analysis of epidemiological studies (选题审校:应颖秋 编辑:王淳) (本文由北京大学第三医院药剂科翟所迪教授及其团队选题并审校,环球医学资讯编辑完成。)
This finding demonstrates that HTLV-1 infection of CD34+ HP/HSCs induces the development of a mature CD4+ T-cell lymphoma within a relatively short time frame (12-20 weeks after reconstitution) with histopathologic, immunologic, and clinical characteristic features of ATLL in HU-NOD/SCID and HU...
Human T-cell leukemia virus type 1(HTLV1) infection in… 下载积分:3000 内容提示: TitleH uman T -cell leukemia virus type 1(H T LV 1) infection inmalignant lymphomas in a H T LV 1-endemic area, Kagoshima,Japan : H T LV -1 in-situ-hybridization (IS H ) analysis employinga high...
(INSTI) candidates built around several chemical scaffolds to determine their effectiveness in limiting HTLV-1 infection. Naphthyridines with substituents in position 6 emerged as the most potent compounds against HTLV-1, with XZ450 having highest efficacy in vitro. Using single-particle cryo-electron...