Altogether, our data point to the possibility that the human thymic epithelial cells play a role in the establishment and progression of HTLV-1 infection, functioning as a reservoir and transmitting the virus to maturing CD4 + T lymphocytes, which in turn will cause disease in the periphery. ...
2021年12月,来自熊本大学等研究机构合作在The Journal of Clinical Investigation发表了“HTLV-1 infection promotes excessive T cell activation and transformation into adult T cell leukemia/lymphoma”的研究论文。该工作利用单细胞转录组和 TCR 测序等技术,证明了人类I型 T 细胞白血病病毒(HTLV-1)可激活 naive T...
2021年12月,来自熊本大学等研究机构合作在The Journal of Clinical Investigation发表了“HTLV-1 infection promotes excessive T cell activation and transformation into adult T cell leukemia/lymphoma”的研究论文。该工作利用单细胞转录组和 TCR 测序等技术,证明了人类I型 T 细胞白血病病毒(HTLV-1)可激活 naive T...
他们的研究结果发表在《The Journal of Clinical Investigation》上的一篇题为“HTLV-1 infection promotes excessive T cell activation and transformation into adult T cell leukemia/ lymphoma”的文章中。 在最初感染HTLV-1数十年后,近5%的感染者发展成ATL。HTLV-1只感染T细胞并将其转化为白血病细胞,但病毒感染...
HTLV-1 infections are explicitly found in all the seven aGVHD patients. Furthermore, the multiplex immunohistology (IMC) results confirm that donor-derived CD4+T cells are increased by HTLV-1 infection. Additionally, joint analysis of mass cytometry (CyTOF) and IMC results suggest the aGVHD-speci...
HTLV-1/2 share molecular and biological characteristics [11,21,24], and the integration of viral nucleic acids into the cellular genome establishes viral persistence and maintains and transmits the virus, which determines the various outcomes of infection [21]. HTLV-1/2 infect lymphocytes that ar...
Background and objectives: Human T-Lymphocyte Virus-1 (HTLV- 1) is known as the etiologic factor of acute T-Lymphocytic Leukemia (ATL) and tropical spastic paralysis. (TSP). Endemic factors causing infection with Human T Lymphocyte Virus-1 (HTLV-1) is based on environmental, socio-economical...
Dr Taylor: The session we have just had is really a first in one sense, because we are talking about the elimination of HTLV-1, the human T-lymphotropic virus type 1, sometimes called human T-cell leukemia virus. We h...
could be induced by HTLV-1 infection in HeLa, PMA-differentiated THP1 cells, primary human monocytes, and human monocyte-derived macrophages. In these cells, the overexpression of Ku70 inhibited the HTLV-1 protein expression, whereas...
4.Human T-cell leukemia virus type I (HTLV-I) infection and the onset of adult T-cell leukemia (ATL) https://retrovirology.biomedcentral.com/articles/10.1186/1742-4690-2-27 5.WHO-寨卡病毒 https://www.who.int/zh/news-room/fact-sheets/detail/zika-virus ...