(2011) Varying modulation of HIV-1 LTR activity by Baf complexes. J Mol Biol 411: 581-596.Van Duyne R, Guendel I, Narayanan A, et al. Varying modulation of HIV-1 LTR activity by Baf complexes. J Mol Biol 2011; 411: 581-96.Van Duyne, R.; Guendel, I.; Narayanan, A.; Gregg,...
To this purpose, the long terminal repeat (LTR) region of HTLV-1 was used. New LTR sequences were obtained from 100 blood samples which infected with HTLV-1. Moreover, all Iranian LTR sequences which have been reported so far, were obtained from GenBank database. Sequences were aligned ...
【方法】将HTLV-1病毒阳性细胞系MT2与HeLa细胞进行共培养,获得病毒早期感染模型,免疫印迹检测病毒核心蛋白p19、凋亡相关蛋白caspase-3/9、自噬相关蛋白LC3;real-time PCR检测病毒载量;荧光素酶活性检测3′长末端重复序列(3′-LTR)转录活性;免...
在HTVL-1的调节及编码基因中,在致病性上起关键作用的有tax和HBZ基因,tax基因有时会因为表观遗传的改变或5’-LTR的缺失而灭活,而HBZ却是唯一一个在所有成人T细胞白血病(ATL)病人样品中都完整稳定表达的基因。HBZ基因通过其mRNA形式促进ATL细胞的增殖,在体实验还发现,HBZ还可以诱导T细胞淋巴瘤和全身性炎症反应的发生...
Mutation rates in LTR of HTLV-1 in HAM/TSP patients and the carriers are similarly high to Tax/ Rex-coding sequence The genomic sequence of human T-cell leukemia virus type 1 (HTLV-1) is highly conserved, although minor sequence variations enable classification of the is... M Saito,Y Fur...
(2010). Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4+ T-cells. Blood 116: 2994–3003. Article CAS PubMed PubMed Central Google Scholar Tabakin-Fix Y, Azran I, Schavinky-Khrapunsky Y, Levy O, Aboud M . (2006). Functional inactivation of p53 by human T...
Tax expression is frequently lost due to DNA methylation in the promoter region, genetic changes to the tax gene, and deletion of the 5' long terminal repeat (LTR) in approximately half of all ATL cases. On the other hand, HBZ is expressed in all ATL cases. HBZ is known to function ...
HBZ主要是通过调节HTLV-1 5、LTR转录,控制一系列与细胞生长、免疫反应和T细胞分化等相关的细胞信 号通路来发挥其作用的。因此,HBZ的多重功能使得它在ATL发病机制中占有 极其重要的作用。关键词:人类T淋巴细胞口血病1型病毒;成人T细胞白血病发病机制;HBZ;Tax1、引言人类T淋巴细胞白血病1型病毒(HTLVJ)是第一个被...
HTLV-1 does not use viral capture of a cellular proto-oncogene for oncogenesis. Its viral oncoprotein, Tax, is needed to initiate but not maintain cellular transformation. Tax transforms cells through various mechanisms, including the creation of chromosomal instability, the amplification of centrosome...
在HTVL-1的调节及编码基因中,在致病性上起关键作用的有tax和HBZ基因,tax基因有时会因为表观遗传的改变或5’-LTR的缺失而灭活,而HBZ却是唯一一个在所有成人T细胞白血病(ATL)病人样品中都完整稳定表达的基因。HBZ基因通过其mRNA形式促进ATL细胞的增殖,在体实验还发现,HBZ还可以诱导T细胞淋巴瘤和全身性炎症反应的发生...