HTLV-1 preferentially infects CD4+ T cells and is maintained by proliferation of the infected T cells. HTLV-1-infected cells rarely express viral antigens in vivo; however, they easily express the antigens after short-term culture. Therefore, such virus-expressing cells may lead to activation ...
PREVALÊNCIA DA INFECÇÃO PELO HTLV-1/2 EM TRÊS MUNICÍPIOS DA REGIÃO METROPOLITANA DE BELÉM-PA Author links open overlay panelFelipe Teixeira Lopes, Bruno José Sarmento Botelho, Bernardo Cintra dos Santos, Ana Carolina Alves Correa, Jayanne Lilian Carvalho Gomes, Vanessa de Oliveira...
Human T-cell leukemia virus type 1 (HTLV-1) infection causes T-cell leukemia and inflammatory diseases, most notably including HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The underlying mechanism for the pathogenesis of HAM/TSP remains unclear. According to a recent clinical...
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Consistently, HTLV-1 molecular clones replicate better and produce more virus particles in PA28γ-deficient cells. These results define a unique and novel role for the cellular factor PA28γ in the control of nuclear RNA trafficking and HTLV-1-induced latency. Importantly, knockdown of PA28γ ...
Papuloerythroderma in a patient with cutaneous T-cell lymphoma infected with HTLV-1 virusThis report shows a case of papuloerythroderma in a patient with cutaneous Tヽell lymphoma infected with HTLVvirus.doi:10.1002/cia2.12001Kasuya AkiraTokura Yoshiki...
Introduction: Patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) become progressively impaired, with chronic pain, immobility and bladder, bowel and sexual dysfunction. Tested antiretroviral therapies have not been effective and most patients are offered a short course of ...