Pyramidal tract damage with myelin and axonal loss, mainly in the lower thoracic spinal cord are observed.The pathogenesis of TSP/HAM is still poorly understood and viral and host factors as the proviral load and the immune response are considered to play a major role in disease progression. ...
Human T cell leukemia virus type 1: persistence and pathogenesis. Annu. Rev. Immunol. 15, 25-53. doi: 10.1146/annurev-immunol- 042617-053222Bangham, C. R. M. (2017). Human T cell leukemia virus type 1: persistence and pathogenesis. Annu. Rev. Immunol. doi: 10.1146/annurev-immunol-...
The HBZ gene, a key player in HTLV-1 pathogenesis. Retrovirology. 2009;6:71. doi:10.1186/1742-4690-6-71. Article PubMed PubMed Central CAS Google Scholar Matsuoka M, Jeang KT. Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and ...
This article outlines the current understanding of HTLV-1 infection and the pathogenesis of these diseases.Access through your organization Check access to the full text by signing in through your organization. Access through your organization
An association between a higher frequency of TAX-specific CD8+ T cells in the CNS of patients with HAM has been described, suggesting the active participation of these cells in the pathogenesis of the disease [45,46]. The presence of intrathecal antibodies against HTLV-1 has been associated wi...
HTLV-1 remains a neglected area of basic and clinical research. Following decades of intensive research on the pathogenesis of HIV-1, the tools now exist to understand the biology of HTLV-1 and for rational therapeutic development to take place. In this study, we aimed to understand whether ...
both ATLL and HAM/TSP are still highly intractable to conventional therapeutics. Therefore, further research to enhance our understanding of the pathogenesis and treatment of HTLV-1 associated diseases is of crucial importance. A topic of intense investigation for HTLV-1-mediated leukemogenesis has bee...
pathogenesisA series of our neuropathological studies was reviewed in order to clarify pathogenesis of human T lymphotropic virus type 1(HTLV-1)-associated myelopathy (HAM)/tropical spastic paraparesis (TSP). The essential histopathologic finding was chronic inflammation in which inflammatory infiltrates...
HTLV-1: persistence and pathogenesis. Virology. 2013;435(1):131–40. 2. Iwanaga M, Watanabe T, Utsunomiya A, Okayama A, Uchimaru K, Koh K-R, et al. Human T-cell leukemia virus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: a nationwide ...
摘要: Pathogenesis of HTLV-1 安永 純一朗 細胞 46(6), 254-257, 2014-06 关键词: HTLV-1 bZIP factor (HBZ Tax Adult T-cell leukemia (ATL 年份: 2014 收藏 引用 批量引用 报错 分享 求助全文 通过文献互助平台发起求助,成功后即可免费获取论文全文。 请先登入相似文献...