HSV-1 感染新发现:宿主基因组 Pol II 耗竭引发 + 1 核小体移位 《Journal of Virology 4.0》:HSV-1 infection induces a downstream shift of the +1 nucleosome 编辑推荐: 这篇研究聚焦于单纯疱疹病毒 1 型(HSV-1)感染,发现其导致宿主转录关闭的同时,会使宿主基因启动子处 + 1 核小体下游移位。该研究揭...
Overall, 42 participants (51.2%) had primary HSV-1 infection, 23 (28.1%) had nonprimary infection, and 17 (20.7%) were classified as unknown. Of 80 participants with sera available 12 weeks after the first symptoms of genital infection, ...
ResultsAmong the 82 participants, the median (range) age was 26 (16-64) years, 54 (65.9%) were women, and 42 (51.2%) had primary HSV-1 infection. At 2 months, HSV-1 was detected from the genital tract in 53 participan...
今天给大家翻译的是2023年《Viruses》期刊文章:A Trivalent HSV-2 gC2, gD2, gE2 Nucleoside-Modified mRNA-LNP Vaccine Provides Outstanding Protection in Mice against Genital and Non-Genital HSV-1 Infection, Comparable to the Same Antigens Derived from HSV-1。 摘要 HSV-1病是一种严重的公共卫生负担,...
近日,Morgane Linard等研究学者在期刊Scientific Reports上发表题为Association between herpes simplex virus infection and Alzheimer’s disease biomarkers: analysis within the MAPT trial的研究论文【2】。研究表明,HSV-1感染(尤其是频繁再激活的感染者和APOE4携带者)与较低的大脑皮层淀粉样蛋白负荷相关,但与血浆生物...
Host protection against cutaneous herpes simplex virus 1 (HSV-1) infection relies on the induction of a robust adaptive immune response. Here, we show that Navsensory neurons, which are involved in pain perception, control the magnitude of CD8 T cell priming and expansion in HSV-1-infected ...
In addition, tetraspanin CD81 regulates HIV reverse transcription through its association with the dNTP hydrolase SAMHD1. Here we aimed at analysing the role of CD81 in Herpes simplex virus 1 infectivity using a neuroblastoma cell model. For this purpose, we generated a CD81 KO cell line using...
They note that roughly 140 million people aged 15 to 49 years have genital HSV-1 infection, primarily in the Americas, Europe, and Western Pacific. "Fewer people in high-income countries are becoming infected with HSV-1 as children, likely due to better hygiene and living conditions, and ins...
Host protection against cutaneous herpes simplex virus 1 (HSV-1) infection relies on the induction of a robust adaptive immune response. Here, we show that Nav1.8+ sensory neurons, which are involved in pain perception, control the magnitude of CD8 T cel
2019年11月,福建医科大学郑春福教授团队应邀在微生物学领域前沿期刊《Frontiers in Microbiology》的专题“The Interplay Between Innate Immunity And Herpesviruses”发表题为“A Tug of War: DNA-Sensing Antiviral Innate Immunity and Herpes...