HSV-1 感染新发现:宿主基因组 Pol II 耗竭引发 + 1 核小体移位 《Journal of Virology 4.0》:HSV-1 infection induces a downstream shift of the +1 nucleosome 编辑推荐: 这篇研究聚焦于单纯疱疹病毒 1 型(HSV-1)感染,发现其导致宿主转录关闭的同时,会使宿主基因启动子处 + 1 核小体下游移位。该研究揭...
HSV-1 is an increasing cause of genital herpes, especially in high-income countries that have a declining rate of oral HSV-1 acquisition during childhood,4,5leaving individuals susceptible at initiation of sexual activity. An “epidemiologic tra...
体外和动物实验已证实HSV-1感染可导致Aβ积累、tau蛋白过度磷酸化和神经元丢失。然而,关于HSV-1感染与人类AD生物标志物之间关系的研究相对较少,且结果不一致【1】。 近日,Morgane Linard等研究学者在期刊Scientific Reports上发表题为Association between herpes simplex virus infection and Alzheimer’s disease biomarker...
Herpesviruses”发表题为“A Tug of War: DNA-Sensing Antiviral Innate Immunity and Herpes Simplex Virus Type I Infection”的文章,该文系统地介绍了I型单纯疱疹病毒(HSV-1)逃逸DNA识别信号通路介导抗病毒天然免疫的最新研究进展,其中包...
今天给大家翻译的是2023年《Viruses》期刊文章:A Trivalent HSV-2 gC2, gD2, gE2 Nucleoside-Modified mRNA-LNP Vaccine Provides Outstanding Protection in Mice against Genital and Non-Genital HSV-1 Infection, Comparable to the Same Antigens Derived from HSV-1。
(1) 感染谱广,能感染多数的肿瘤细胞系。因为溶瘤单纯疱疹病毒能够选择性地在干扰素信号通路缺陷的瘤细胞内生长繁殖并杀伤瘤细胞,而这部分瘤细胞占总的瘤细胞的比例超过90%; (2) 感染效率高,活性强且溶瘤所需时间短,能以很低的感染复数(multiply ofinfection,MOI)杀伤肿瘤细胞,并能高效激活免疫细胞如CD4+/CD8+...
新生儿单纯疱疹病毒感染多见于早产儿，也可以发生在足月儿。病变常累及全身多个器官。单纯疱疹病毒为双股DNA病毒，可分为两型，Ⅰ型主要引起唇、口周、齿龈及咽部皮肤黏膜疱疹；Ⅱ型引起生殖器疱疹。新生HSV感染多由Ⅱ型，偶由Ⅰ型所致。HSV具有能长期潜伏、反复发作及嗜神经组织的特点。病因 大多数新生儿是在产时经...
Latent HSV1 virus could be addressed by rare cutting endonucleases, such as specific meganucleases. Methods Co‐transfections with plasmid expressing I〤reI variants cleaving target sequences and GFP were performed using Lipofectamine on BSR cells for 48 hours. After infection for 8h with SC at ...
CONCLUSIONSIn a study population that was representative of the general population of HSV-1– and HSV-2–seronegative women, the investigational vaccine was effective in preventing HSV-1 genital disease and infection but not in preventing HSV-2 disease or infection. ...