The HSV-1 strain generally appears in the orafacial organs. All herpes viruses are morphologically iden- tical: they have a large double-stranded DNA genome and the virion consists of an icosahedral nucleocapsid which is surrounded by a lipid bilayer enve- lope. Following primary infection, the ...
QuestionWhat are the rates of viral shedding after first-episode genital herpes simplex virus type 1 (HSV-1) infection? FindingsIn this prospective cohort study, 82 participants with first-episode genital HSV-1 infection, of whom 42...
like primary infection, reactivation doesn’t cause any symptoms, but when it does, the most common pattern is having a handful of blisters at the vermillion border—the border of the lip—on one side of the face. These blisters are typically smaller and heal over a week. ...
hippocampus, or subventricular zone (Fig.1D). Taken together, the results suggest the CS contributes directly to viral surveillance in the peripheral and central nervous system during acute primary infection that leads to the demise of mice following ocular virus infection. ...
293T, HeLa cells, Vero cells, and HSV-1 were purchased from ATCC. The Solute Carrier Transporter SLC15A3 Participates in Antiviral Innate Immune Responses against Herpes Simplex Virus-1 During primary infection, which occurs 4 to 12 days after sexual exposure and in the absence of pre-existing...
根据发表于《新英格兰医学》(NEJM)杂志上的结果,一种研究性疫苗能保护一些女性免于两种单纯疱疹病毒之一的能引起生殖器疱疹的病毒的感染。该疫苗部分有效地防止单纯疱疹病毒1型(HSV-1)的感染,但不能保护女性免受单纯疱疹病毒2型(HSV-2)的感染。 据《每日科学》报道,根据发表于《新英格兰医学》(NEJM)杂志上的结果...
Herpes stromal keratitis (HSK) is an immunoinflammatory disease that is triggered by herpes simplex virus (HSV) infection of the cornea. Most herpetic eye disease is caused by HSV type 1 (HSV-1). Primary HSV-1 infection often occurs early in life and with minimal or no symptoms. However,...
(1) 感染谱广,能感染多数的肿瘤细胞系。因为溶瘤单纯疱疹病毒能够选择性地在干扰素信号通路缺陷的瘤细胞内生长繁殖并杀伤瘤细胞,而这部分瘤细胞占总的瘤细胞的比例超过90%; (2) 感染效率高,活性强且溶瘤所需时间短,能以很低的感染复数(multiply ofinfection,MOI)杀伤肿瘤细胞,并能高效激活免疫细胞如CD4+/CD8+...
The Role of Lipid-Lowering Drugs in Controlling Dengue Virus Infection Antiretroviral Drug Lamivudine Shows Promise for Alzheimer’s Treatment in Early Trials Management of Cognitive Impairment Associated with Post-COVID-19 Syndrome: Recommendations for Primary Care ...
oral HSV-1 as they enter their sexually active years, when exposure genitally is increasingly common: "Almost one in 10 adolescents who 10 years ago already would have acquired HSV-1 earlier in life now are vulnerable to getting a primary infection" as they become sexually active later in ...