High levels of HSV-1 and HSV-2 in female sex workers in London. Epidemiol Infect. 2006 Oct; 134 (5):1114–1119.Fox J, Taylor GP, Day S, et al. How safe is safer sex? High levels of HSV-1 and HSV-2 in female sex workers in London. Epidemiol Infect 2006;134:1114e19....
Howsafeissafersex?HighlevelsofHSV-1andHSV-2in femalesexworkersinLondon J.FOX1*,G.P.TAYLOR1,S.DAY2,J.PARRY3ANDH.WARD4 1DepartmentofGenitourinaryMedicineandInfectiousDisease,ImperialCollegeLondon,UK 2DepartmentofAnthropology,Goldsmith’sCollege,UniversityofLondon,UK 3SexuallyTransmittedandBloodborneVirus...
we recently reported that cells that expressed a dominant negative (DN) form of IκBα displayed high levels of apoptosis when infected with wild type HSV-1.31 These results support a role for NF-κB activation in preventing apoptosis during HSV infection that can vary with respect to the conte...
U2OS cells, in which ICP0 is not required for normally efficient HSV-1 infection (40) but which express wild type p53, were analyzed for their ability to undergo UV-induced apoptosis following infection. High levels of UV irradiation have been shown to induce the stabilization of p53, ...
Culture supernatants of PB T cells stimulated with recombinant gH(t(His)):gL contained high levels of interferon-gamma and no detectable interleukin-4, indicating their Th1 phenotype. These results show that naturally acquired HSV-1 infection induces gH:gL-specific humoral and T cell responses. ...
We chose 6 regions where high levels of RNA Pol II binding locate beside CTCF binding sites detected by ChIP-seq and examined the effects of CTCF knockdown on the RNA Pol II forms. We found that in all 6 regions, the Ser2P form of RNA Pol II reduced after CTCF knock- down, while ...
HSV-1 envelope glycoprotein gD (HSV-gD) gradually increased with increasing infection time, indicating that HSV-1 infected microglia and expanded. It began 12 h after HSV-1 infection, and GM130 protein levels gradually decreased (p < 0.001, Fig. 1c–f). The TLR3 protein increased ...
In contrast in mouse neuroblastoma cells expressing LAT, AKT, and pAKT levels remained high. AKT is a serine/threonine protein kinase that promotes cell survival. To examine the effect of LAT on AKT-pAKT using a different and more rapid method of inducing apoptosis, a stable cell line ...
High levels of Th1-type cytokines (e.g., IFN-γ, IL-2 and IL-12) tend to favor the induction of cell mediated immune responses to an administered antigen. In contrast, high levels of Th2-type cytokines (e.g., IL-4, IL-5, IL-6, IL-10 and TNF-13) tend to favor the ...
CJ9-gD is a completely replication-defective HSV-1 recombinant which inhibits replication of wild-type HSV-1/-2 in co-infected cells (dominant-negative effect). Moreover, it expresses high levels of HSV-1 major antigen glycoprotein D (gD). Immunization with CJ9-gD induces strong and long-...