Closely spaced deletions across the promotor region at the 5′ end indicate that at least 95 nucleotides of 5′ flanking DNA upstream from the TATTAA transcription signal are required for quantitive synthesis of TK mRNA in Xenopus oocytes.
Furthermore, inhibition of IFN-b production by methyl thioadenosine34, a signal transducer and activator of transcription 1 inhibitor, did not alter the capacity of Poly(I:C) to reduce HSV-1 gD expression (Supplementary Fig. S1a,b). These results indicated that although IFN-b has well- ...
Further, certain sequence features around individual transcription units are shared: HSV promoters contain TATA and often CATC boxes, and the sequence signal indicating a polyadenylation site (AATAAAA) is standard. In spite of these similarities, there is one very distinct difference between the ...
Recent research has revealed that the GA may be a signal transduction organelle that promotes a variety of innate immune pathways, including the TLR3 signaling pathway [19]. Our previous studies have suggested that HSV-1 can cause downregulation of GM130 and fragmentation of GA, while knocking ...
This allowed quantifying poly(A) site usage of all viral genes except the lowly expressed RL1 gene (Supplementary Data 4; see Fig. 9 for the UL39–50 gene segment). Viral poly(A) sites were almost exclusively (42/45) preceded by an AAUAAA poly(A) signal. Three additional, weakly ...
gB蛋白由UL27基因编码,全长904个氨基酸,结构如图1所示,从N端至C端依次为信号肽(signal peptide,SP)、胞外域(extracellular domain,ECD)、膜近端区(membrane proximal region,MPR)、跨膜结构域(transmembrane domain,TM)以及胞浆区(cytoplasmic domain,CTD)。gB蛋白的融合能力来源于胞外域,其中包含I、II、III、IV、...
(A)立即;(B)注射后45分钟; (C)注射后24小时; 和(D)注射后48小时拍摄右臂注射部位的照片。[0041]图3显示在施用500μg剂量的COR-1疫苗后受试者的注射部位的照片。(A)立即;(B)注射后45分钟; (C)注射后24小时; 和(D)注射后48小时拍摄左臂注射部位的照片。
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Thus, although a new sensor, DDX41, has recently been shown to signal through a STING-depend- ent manner similar to that of p204,31 the loss of p204 seems to facilitate the major if not sole contribution to innate immu- nity of the cornea as seen by a loss of viral containment ...
first VP16 responsive element at 149 bp upstream of the HCMV TATA element and the second VP16 responsive element at 274 bp upstream of the HCMV TATA element, 2) beta-globin intron, and 3) a codon optimized tetR coding sequence followed by SV40 poly A signal sequence (SEQ ID NO: 7)....