(A)立即;(B)注射后45分钟; (C)注射后24小时; 和(D)注射后48小时拍摄右臂注射部位的照片。[0041]图3显示在施用500μg剂量的COR-1疫苗后受试者的注射部位的照片。(A)立即;(B)注射后45分钟; (C)注射后24小时; 和(D)注射后48小时拍摄左臂注射部位的照片。
gB蛋白由UL27基因编码,全长904个氨基酸,结构如图1所示,从N端至C端依次为信号肽(signal peptide,SP)、胞外域(extracellular domain,ECD)、膜近端区(membrane proximal region,MPR)、跨膜结构域(transmembrane domain,TM)以及胞浆区(cytoplasmic domain,CTD)。gB蛋白的融合能力来源于胞外域,其中包含I、II、III、IV、...
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[7]Takeshita F, Gursel I, Ishii K J, et al. Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9.[J]. Semin Immunol, 2004, 16(1): 17-22. [8]De G E, Srinivas S, Kilkenny C, et al. Differential activities of the RET tyrosine kinase recept...
L. (1994) Efficient particle formation can occur if the matrix domain of human immunodeficiency virus type-1 gag is substituted by a myristylation signal J Virol 68, 6644–6654 PubMed CAS Google Scholar Prange, R., Clemen, A., and Streeck, R. E. (1991) Myristylation is involved in ...
Closely spaced deletions across the promotor region at the 5′ end indicate that at least 95 nucleotides of 5′ flanking DNA upstream from the TATTAA transcription signal are required for quantitive synthesis of TK mRNA in Xenopus oocytes.
Further, certain sequence features around individual transcription units are shared: HSV promoters contain TATA and often CATC boxes, and the sequence signal indicating a polyadenylation site (AATAAAA) is standard. In spite of these similarities, there is one very distinct difference between the ...
while the signal of free HSV-1 weakened rapidly at the tumor site in 3 h, confirming that silk-hydrogels extend the localized retention of the virions at the tumor site (Fig.3h). Consistently, Virus@gel enhanced the GFP signal of HSV-1 and the HSV-1 genomic DNA level at the tumor...
Recent research has revealed that the GA may be a signal transduction organelle that promotes a variety of innate immune pathways, including the TLR3 signaling pathway [19]. Our previous studies have suggested that HSV-1 can cause downregulation of GM130 and fragmentation of GA, while knocking ...