To investigate the mechanism of Golgi matrix protein 130(GM130) regulating the antiviral immune response of TLR3 after herpes simplex virus type 1(HSV-1) infection of microglia cells. We explored the regulatory effects of berberine on the immune response
To investigate if viral-derived factors contribute to their recruitment to the skin, we injected mice with either HSV-1 (a normal dose of 106 pfu, or a high dose of 107 pfu) or saline intradermally and analysed the skin at 6 hr p.i. (Fig. 1e). Intradermal injection creates...
Myeloid cell infiltration in C3 KO mice increases above WT mice in response to HSV-1 infection Components of the CS are potent chemoattractants for granulocytes and monocyte/macrophage populations45. As chemokines associated with recruitment of these cells including CXCL1 and CCL2 were also found to...
To determine if vFGF2 protein was synthesized in the absence of viral replication, transductions were carried out as described above in the presence of the anti-HSV-1 nucleoside analog acycloguanosine ACG (Fig. 2). The vFGF2 was expressed in Vero cells transduced with 2526/FGF2 and 5042/...
Progress in HSV vaccine development As described above, the biological complexities, patho- genesis, and immune evasion mechanisms of HSV infec- tion are profound, leading to complex clinical symptoms and posing significant challenges to the development of antiviral drugs and vaccines. The FDA has ...
Only nodes with bootstrap support above 70% are shown. Abbreviation (common name), virus name, protein accession number, RING domain region: HHV1 (HSV-1), Human α-HV 1, YP_009137074.1, 113:167; PanHV3, Chimpanzee herpesvirus strain 105640, YP_009010986.1, 121:175; HHV2 (HSV-2), ...
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The data presented above suggest that microglia rely on STING to activate antiviral defense, and also that there is STING-dependent transfer of antiviral signals through the tissue in the CNS. Type I IFNs are pivotal for control of HSV-1 replication in the CNS, and we therefore wanted to ...
Data with error bars depict mean ± standard deviation (SD); with significance ***p < 0.001 indicated above bars. b IB of VP16 and β-actin in SVEC4-10 cells infected by FmutRHIM or UV-irradiated virus at 4 and 16 hpi. c, d Cell viability of SVEC4-10 cells infected with HSV1...
As a control for the specificity of immuno-staining, tissues were processed as above, except that non-immune rabbit serum was substituted for the primary HSV-1 antiserum.Titration of Virus from Tumor and Brain:Mice were sacrificed by lethal injection of anesthesia. Brains with or without in ...