To investigate the mechanism of Golgi matrix protein 130(GM130) regulating the antiviral immune response of TLR3 after herpes simplex virus type 1(HSV-1) infection of microglia cells. We explored the regulatory effects of berberine on the immune response
This truncated form of gC binds 3 MARCO 2 1 KD = 7.7x10−10 0 Bmax = 2.3x10−9 0 10 20 30 Total gC added (nM) 4 MARCO 3 2 1 r 2= 0.95 0 0 2 4 6 8 10 1/Total gC added (nM) MARCO directly binds to HSV-1 gC. The experiments descri- bed above implied that ...
To investigate if viral-derived factors contribute to their recruitment to the skin, we injected mice with either HSV-1 (a normal dose of 106 pfu, or a high dose of 107 pfu) or saline intradermally and analysed the skin at 6 hr p.i. (Fig. 1e). Intradermal injection creates...
HSV-1主要通过口腔到口腔接触传播，导致口腔内或口腔周围感染（口腔疱疹）。然而，HSV-1也可以通过口腔-...
As cited above, several viruses have been shown to inactivate p53 by a number of different mechanisms, presumably to protect infected cells from p53-mediated responses such as apoptosis. Although HSV-1 has been reported to encode a number of proteins that inhibit infected cells from initiating an...
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Finally, a remarkably high number (305 of 685 ¼ 44.5%) of long intergenic non-coding RNAs (lincRNAs) appeared to be upregulated in 4sU-RNA (Fig. 3c). HSV-1 disrupts transcription termination. When analysing genes that were transcriptionally induced but not translated, we observed massive...
. For UV inactivation, virus suspension was exposed in Petri dish for 150 s to UV light at an intensity of 30 watts from a germicidal lamp situated 10 cm above the sample. For pharmacological IκBα phosphorylation inhibition, U937 cells were pre-treated with 1 μM of Bay 11–7085 16 h...
As noted above, the DNA may be present within any of a variety of delivery systems known to those of ordinary skill in the art, including nucleic acid expression systems, bacteria and viral expression systems. Numerous gene delivery techniques are well known in the art, such as those ...
surface-antigen of a HSV) and determine whether a respective antibody is capable of detecting/binding to a given domain, an antigen, preferably a surface-antigen of a HSV, preferably HSV-1 and/or HSV-2 based on the skilled person's common general knowledge and the methods described above.In...