We here aimed to investigate the anti-tumor activity of a novel monoclonal antibody (mAb) 11C9 and identify the antibody tractable target in the hepatocellular cancer stem cells (HCSCs). Methods: The identification of the targeted antigen was conducted using SDS-PAGE, western blot, mass ...
Knowing the AOA status in the infertile women and planning appropriate immunosuppressive therapy would not only ensure the effectiveness of the IVF-ET but also reduce the time invested by the clinician and the cost to be incurred by the patients and thereby restore fertility [50]. The precise ...
Drug resistance and tumor heterogeneity are formidable challenges in cancer medicine, which is particularly relevant for KRAS-mutant cancers, the epitome of malignant tumors recalcitrant to targeted therapy efforts and first-line chemotherapy. In this st
The alleviation of distress during the reliving process between therapy sessions was linked to the resolution of PTSD symptoms, but this pattern was not present in cases of PGD. This indicates that although reliving might be a helpful treatment approach for both conditions, its mechanics likely ...
Monoclonal antibody, 1G6-D7, against eHsp90α blocks exosome-mediated communication from tumour cells to stromal cells If tumour-secreted exosomes carry eHsp90α on their external surface, we anticipated that an anti-eHsp90α neutralizing monoclonal antibody would block the communication from tumour...
Thereafter, the sample was incubated with 1 µg of rabbit polyclonal anti-HSP90 antibody (Santa Cruz Biotechnology, Santa Cruz, CA), mouse monoclonal anti-lamin A/C (Santa Cruz Biotechnology), or isotype-controlled rabbit or mouse IgG (Santa Cruz Biotechnology) overnight at 4 °C on ...
Therefore, we discovered a novel HSP90 inhibitor HCP1 that had better biological activity and provided us a useful tool to explore the underlying mechanism of lung cancer therapy. Graphical abstract Download: Download high-res image (147KB) Download: Download full-size image...
EMT events are correlated with metastatic recurrence following surgery (18, 24), and have recently been observed concurrently following androgen withdrawal therapy (25). Therefore, the ability to identify primary tumor cells with an increased propensity to undergo EMT-like events would improve ...
Autophagy functions under stress, such as hypoxia, nutrient limitation and certain forms of therapy. Cancer cells might upregulate autophagy due to their metabolic dependency on the catabolic process for survival. At the late stage of autophagy, lysosomes maintain a suitable acidic lumen (pH 4.5–5.0...
(NOS) inhibitor, such as an iNOS or an nNOS inhibitor; an inhibitor of the release, or action, of tumour necrosis factor .alpha.; an antibody therapy, such as a monoclonal antibody therapy; an antiviral agent, such as a nucleoside inhibitor (e.g. lamivudine) or an immune system ...