To evaluate and model the pharmacokinetic and pharmacodynamic behavior in rats of FG-3019, a human monoclonal antibody targeting connective tissue growth factor (CTGF). Methods FG-3019, human CTGF (rhCTGF), or the N-terminal domain of rhCTGF were administered intravenously to rats and concentration...
Ganetespib decreases neutrophil accumulation in lung and suppresses anti-PD-1 reactive IgG1 antibody accumulation The HSP90 inhibitor, ganetespib, plays a major role in the sta- bility and activity of a diverse range of HSP90 client proteins and signaling pathways including JAK/STAT, RAF/MEK/ERK...
HuLuc63 inhibited MM cell binding to BMSCs and induced antibody-dependent cellular cytotoxicity (ADCC) against MM cells in dose-dependent and CS1-specific manners. HuLuc63 triggered autologous ADCC against primary MM cells resistant to conventional or novel therapies, including bortezomib and HSP90 ...