BackgroundMouse hepatocarcinogenesis is associated with mutations in Hras, but infrequently in Kras. The effect on carcinogenesis of developmental age at the time of ras mutation remains unknown.AimWe sought to compare quantitatively the effects of expressing mutant H- or Kras genes in fetal vs. adu...
The effect on carcinogenesis of developmental age at the time of ras mutation remains unknown. Aim: We sought to compare quantitatively the effects of expressing mutant H- or Kras genes in fetal vs. adult mouse liver. Methods: We established an inducible system of gene expression in mouse ...
and AKT1 encoded byAKT1(right). The mutations in these three genes are shown on thex-axis, and the height of each “lollipop” indicates the frequency of the mutation (y-axis). Missense mutations are depicted as green circles, and small insertions and deletions are shown in black...
slowing proliferation of a neoplasm, and/or reversing proliferation of a neoplasm, for cancers, tumors, and neoplasms harboring a constitutively active variant of one or both of KRAS or HRAS, where the constitutively active variant is a gain of function mutation, a duplication, or a gene amplifi...
Introducing a C118S mutation into wild-type KRAS impairs HRASG12V-driven tumor growth.Lu, Huang
slowing proliferation of a neoplasm, and/or reversing proliferation of a neoplasm, for cancers, tumors, and neoplasms harboring a constitutively active variant of one or both of KRAS or HRAS, where the constitutively active variant is a gain of function mutation, a duplication, or a gene amplifi...
The prevalence of KRAS mutation was not significantly different between HRASmt and HRASwt tumors across all investigated tumor types. However, significant differences in the prevalence of KRASmt G12C were observed in HRASmt vs. HRASwt in HR+/HER2- BC (5.9 vs. 0.1%), HNSCC (2.7 vs. 0.1%...