doi:10.1002/mc.23813Brogna, Marianna RitaCollina, FrancescaChiofalo, Maria GraziaDe Bartolo, DeboraMontone, AngelaSchiano, Maria RosariaDel Sesto, MichelePizza, NubiaFerrara, GerardoMolecular Carcinogenesis
and AKT1 encoded byAKT1(right). The mutations in these three genes are shown on thex-axis, and the height of each “lollipop” indicates the frequency of the mutation (y-axis). Missense mutations are depicted as green circles, and small insertions and deletions are shown in black...
slowing proliferation of a neoplasm, and/or reversing proliferation of a neoplasm, for cancers, tumors, and neoplasms harboring a constitutively active variant of one or both of KRAS or HRAS, where the constitutively active variant is a gain of function mutation, a duplication, or a gene amplifi...
slowing proliferation of a neoplasm, and/or reversing proliferation of a neoplasm, for cancers, tumors, and neoplasms harboring a constitutively active variant of one or both of KRAS or HRAS, where the constitutively active variant is a gain of function mutation, a duplication, or a gene amplifi...
Introducing a C118S mutation into wild-type KRAS impairs HRASG12V-driven tumor growth.Lu, Huang
The effect on carcinogenesis of developmental age at the time of ras mutation remains unknown. Aim: We sought to compare quantitatively the effects of expressing mutant H- or Kras genes in fetal vs. adult mouse liver. Methods: We established an inducible system of gene expression in mouse ...