Patients with chronic lymphocytic leukemia (CLL) carrying deletion of 17p (17p) or mutations of TP53 have a uniquely poor prognosis related to increased propensities to progress to symptomatic disease, poor responses to chemo(immuno)therapy and high rates of Richter transformation. Both traditional ...
random mutation during cell division, resulting in uncontrolled cell growth. Mouse models of BRCA-related cancers have demonstrated that damage to genes, such as TP53, occurred prior to damage to the second copy of BRCA.Ben Ho Park, M.D., Ph.D., associate professor of oncology at the ...
Furthermore, the TP53/KMT2C common mutation can predict the response of NSCLC patients to ICI as well. Soecifically, one study found that PFS was significantly better in patients with co-mutation, possibly because patients with co-mutation of TP53/ KMT2C had significantly higher initial CD8(...
The mutation of E3 ligase FBW7 and resulting stabilization of MCL-1 protein is critical in tumorigenesis of T- acute lymphocytic leukemia (T-ALL)50, and determines the sensitivity of cancer cells to anti-microtubule drugs51. Thus far, the genetic mutations harbored by BCL-2 family proteins ...
How best to manage patients with chronic lymphocytic leuekmia with 17p deletion and/or TP53 mutation?[J] . Constantine S. Tam,Stephan Stilgenbauer.Leukemia & Lymphoma . 2015 (3)Constantine S., TamStephan, Stilgenbauer. (2015) How best to manage patients with chronic lymphocytic leuekmia ...
Here, we report a vertebrate mutant model system for studying U8 snoRNA function. Zebrafish U8 mutants were found to exhibit defective rRNA biogenesis and activation of the tumor suppressor p53 (tp53), which monitors ribosome biogenesis dysfunction in a regulatory loop known as “nucleolar stress sur...
The ratio of statistically sig- nificant gene expression studies was similar between the genes also known to be involved in Mendelian-inherited disorders or not (27 out of 58 vs. 31 out of 62; 2-test, 1 degree of freedom: 0.4; P ϭ 0.46). The ratio of statistically significant ...
cerebral blood volume (rCBV) MRI, a robust and non-invasive estimate of tumor angiogenesis, showed in a cohort of 73 patients that a one-unit increase in rCBV corresponds to a two-thirds decrease in the odds of an IDH mutation and correctly predicts IDH mutation status in 88% of patients...
Mutations, or defects, in HRR pathway genes - which include ataxia telangiectasia mutated (ATM) and BRCA1/2 genes - increase the risk for breast, ovarian, pancreatic, prostate and other cancers. AstraZeneca - LYNPARZA Phase III PROfound trial in HRR mutation-selected metastatic castration-resista...
To test the idea, Park’s team first selected cell lines derived from non-cancerous human breast epithelial cells – where BRCA1 breast cancers originate. They then used an advanced gene-targeting technique to create new cell lines that have a typical cancer-linked BRCA1 mutation in only one...