We studied general and cancer related distress in 85 healthy women with a 25% or 50% risk of being carrier of aBRCA1/BRCA2 gene mutation and 66 partners in the six to eight week period between genetic counselling/blood sampling and disclosure of the test result. Questionnaire and interview ...
or50% risk of being carrier of a BRCA1/BRCA2 gene mutation and 66 partners inthe six to eight week period betweengenetic counselling/blood sampling anddisclosure of the test result.Questionnaireand interview data are analysed. Associa-tions are explored between levels of dis-tress and (1) ...
E Toromanoff - 《Tetrahedron》 被引量: 21发表: 1980年 An entire exon 3 germ-line rearrangement in the BRCA2 gene: pathogenic relevance of exon 3 deletion in breast cancer predisposition Background Germ-line mutations in the BRCA1 and BRCA2 genes are major contributors to hereditary breast/ova...
Paula Shares How Friends And Family Reacted To Her Ovarian Cancer Diagnosis ... 13 of 30 Paula Shares How She Learned Her Daughter Had Ovarian Cancer (VIDEO) 14 of 30 Paula Shares If She Has Been Tested For The BRCA1 Gene (VIDEO) 15 of 30 Paula Shares If She Could Visit Her ...
Germline mutations in high-penetrance breast cancer susceptibility genes BRCA1 andBRCA2 have been strongly implicated in the genetic predisposition of approximately 20% of familial breast cancers.Although BRCA1 and BRCA2 do not account for all familial breast cancers, there are currently no other ...
public health INTRODUCTION Background and purpose During the years prior to the turn of the century, scientific and medical attention for genetic disorders was mainly focused on under- standing rare single-gene disorders, such as Huntington's disease, Duchenne muscular dystrophy, and cystic fibrosis ...
Why is it possible for one of a pair of identical twins to develop retinoblastoma, but not the other? a. The diagnosed sibling has an allele from the father, but the other does not. b. The other sibling is immune to it. c. The normal gene is dominan ...
Cancer gene mutation testsshow specific inherited gene mutations that may develop into cancer. Examples include gene mutations that indicate breast, ovarian, and other types of cancer labeled BRCA1 and BRCA2, etc. Tumor marker testsdetect tumor marker chemicals/proteins that are produced by tumors ...
To test the idea, Park’s team first selected cell lines derived from non-cancerous human breast epithelial cells – where BRCA1 breast cancers originate. They then used an advanced gene-targeting technique to create new cell lines that have a typical cancer-linked BRCA1 mutation in only one...
Mutations in BRCA1 and BRCA2 have been reported in African-American women, but the extent of the contribution of BRCA1 and BRCA2 to breast cancer burden in Africa was uncertain. Limited financial resources lead to suboptimal cancer data collection, as well as delayed diagnosis and treatment of...