PI3K inhibition activates SGK1 via a feedback loop to promote chromatin-based regulation of ER-dependent gene expression. Cell Rep. 27, 294–306.e5 (2019). Article CAS PubMed PubMed Central Google Scholar Toska, E. et al. PI3K pathway regulates ER-dependent transcription in breast cancer ...
Paula Shares How Friends And Family Reacted To Her Ovarian Cancer Diagnosis ... 13 of 30 Paula Shares How She Learned Her Daughter Had Ovarian Cancer (VIDEO) 14 of 30 Paula Shares If She Has Been Tested For The BRCA1 Gene (VIDEO) 15 of 30 Paula Shares If She Could Visit Her...
Dr. Francis: So there’s two parts to this, one is knowing that you already have a gene, and what are your options. And the second part is, how do you get to the point of finding out you have a gene. So, not everybody needs to be tested for these genetic conditions, you have...
Julie Shares If She Was Scared To Get Tested For Ovarian Cancer (VIDEO) 18 of 19 Julie Shares Symptoms She Had Before Ovarian Cancer Diagnosis (VIDEO) 19 of 19 Julie, who was previously diagnosed with breast cancer, explains how ovarian cancer has changed her life. This Video Improved ...
Prevent disease.Once you know you carry a certain gene, you may be able to make lifestyle changes or get medical treatment so you don’t get sick. For example, women who carry the BRCA1 or BRCA2 gene mutation are at higher risk forbreast cancer. To lower their risk, they may choose...
In very future, majority of the population will have access to their genetic background and they will be able to take it their doctor and will expect to receive personalized treatment rather than a drug that has worked for millions of people but not guaranteed to work for them. Pharmaceutical...
Currently only a fraction of the cancer genes listed in the Cancer Gene Census have drugs or chemical leads that act on the cognate protein. This means that there are very large numbers of cancer genes that remain to be drugged. For example, we have no drugs that work directly on mutant ...
We proceeded to examine whether this mechanism of recombinational repair involving RNA−DNA recombinant bridges can facilitate DSB repair as modeled in Fig.1a. For example, we tested whether RAD52 promotes RNA-bridging of a model DSB containing blunt ends, which is often referred to as a “cl...
three quarters of them knew about her double mastectomy but the rest of what they knew was muddy. Less then 10% of the survey participants could assess Jolie Pitt’s risk as a carrier of the BRCA gene versus a woman who isn’t one. “Awareness of the Angelina Jolie story was not assoc...
"The theory that we tested in the retina can be relevant for understanding the complexity of many other systems, because if you have noisy input-output elements it's better to average their output. And if the elements are slightly more capable they can be more specific and divide up the dy...