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Here, we propose to deconvolve the effects of the different players - material surface, air/liquid interface, agitation - to decipher their role in protein aggregation. We extended this analysis from purified model proteins to a cellular extract composed of thousands of different proteins to identify...
Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection Front. Med., 14 (2020), pp. 185-192 Google Scholar [63] J. Shang, G. Ye, K. Shi, Y. Wan, C. Luo, H. Aihara, Q. Geng, A....
CRISPR/Cas9 was employed to disrupt the U8-3 locus. Creating insertion and/or deletion events in a non-coding RNA could lead to unpredictable consequences for U8-3 function. Consequently, two guides were used to excise U8-3 from the genome, producing a null allele, herein referred to as Δ...
reduced production of mature miRNA due the impairment of their processing by Drosha after editing of hairpin structures in primitive miRNA [21,44]. Although we could not evaluate miRNA abundance or mutations due to the method used to extract RNA, it is worth noting that YAP activation has been...
Immune evasion strategies by inhibiting cyclic GMP-AMP synthase (cGAS) associated stimulator of interferon gene (STING), a retinoic acid-inducible gene I (RIG-I) and Toll-like receptor (TLR) pathways, that are known to induce an immune response by sensing DNA and RNA viruses [[5], [6],...
These phytochemicals, such as phenolic compounds and tannins, have been demonstrated to exhibit antimicrobial activity against a wide range of bacteria and viruses. In addition, the combination of these phytochemicals within an extract can often exhibit a synergistic effect, resulting in an even ...
The water from the last rinse was collected in a 15 mL Falcon tube and half the volume was seeded on Potato Dextrose Agar (PDA) medium in duplicate; the other half was subjected to DNA extraction for the validation of the disinfection method. After surface disinfection, the samples were ...
1.3.1. From Crystal-like Needles to ‘Ribonucleoprotein’ Helices Right time, right person, right place—and the right portion of luck: In the early 1930s, the chemist Wendell M. Stanley accepted the challenge to extract the TMV compound at the Rockefeller Institute for Medical Research in Pri...
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