Basicity of Amines And pKaH Nucleophilic Acyl Substitution (With Negatively Charged Nucleophiles) What makes a good leaving group? Five Key Factors That Influence Acidity Note 1. The limit to using water as solvent for pKameasurements is the levelling effect. That is, no base can exist that is...
Given that neutral resonance structures are preferred overall, when a resonance structure absolutely must bear a negative charge somewhere,place it on the atom best able to stabilize that charge.Since, in essence, “basicity is the opposite of stability”, this is the same as saying, “put the...