Protein-protein interactions (PPIs) play vital roles in life and provide new opportunities for therapeutic interventions. In this large data analysis, 3,300 inhibitors of PPIs (iPPIs) were compared to 17 refere
protein-protein interaction, mutation, cancer, networkThe acquisition of mutations that activate oncogenes or inactivate tumour suppressors is a primary feature of most cancers. Mutations that directly alter protein sequence and structure drive the development of tumours through aberrant expression and ...
efforts were devoted to the study of protein-protein interactions. Large-scale experiments on whole genomes allowed the identification of interacting protein pairs. However residues involved in the interaction are generally not known and the majority ...
The webinar will cover: PICO as a protein-protein interaction approach based on digital PCR How PICO and other methods were used to identify and confirm MHC class II proteins as mediators of cross-species entry of bat influenza viruses Future directions for PICO techno...
Thus, in a protein–protein interaction network, the degree of a gene is the number of proteins that the product of the gene interacts with. The degree distribution of a network describes the frequency of nodes in that network with a given degree: many networks of biological interest show a...
Before summarizing these in turn, we first survey some history and the issue that underpins all molecular modelling — the ability to estimate energy of interaction. Access through your organization Check access to the full text by signing in through your organization. Access through your ...
By targeting displacement with the bipNb, we were able to monitor the amount of neutralizing antibodies from serum samples of infected or vaccinated individuals on a high-throughput basis. This can be used, for example, to check whether an infected person has produced antibodies that protect ...
So they check in various increments to ensure that everyone is posting at the right time. And honestly, I think what it goes back to since we have it, we don’t have it on a massive scale right now. We’re able to really trust the people that we partner with and we do check ...
The electron density map of the variable region of one of the molecules was too poorly defined to build a model due to the high flexibility of the protein. Nevertheless we were able to construct a model of the other molecule, although the residues from L-Ile150 to L-Gln156, from L-...
Always check to see if your sample type has been validated by the manufacturer. ELISA kits can be validated for a wide range of samples, including cell culture supernates, serum, plasma (heparin, EDTA), cell lysate, and tissue. We want to select an ELISA kit that is compatible with ...