Polygenic risk scoresPooled cohort equationLifestylePurpose of Review The potential of polygenic risk scores (PRS) to improve atherosclerotic cardiovascular disease (ASCVD) risk assessment and management has stoked significant interest in their incorporation into clinical management. The goal of this review...
Another example of data-driven bias in healthcare involves polygenic risk scores that use data from genome-wide association (GWAS) studies to calculate a person’s inherited proneness to disease (Norori et al. 2021). Although a polygenic risk score has excellent potential as a predictive biomarker...
The second-largest preventable risk to all cancers after smoking is obesity6, which has been extensively studied in relation to breast cancer. In observational studies, there is consistent evidence for a positive association of increased body mass index (BMI) with post-menopausal breast cancer, but...
Polygenic risk scores (PRS) are promising for identifying common variant‐related inheritance for psychiatric conditions but their integration into clinical practice depends on their clinical utility and psychiatrists'' understanding of PRS. Our online survey explored these issues with 276 professionals ...
PUSHING THE ENVELOPE WITH POLYGENIC RISK SCORES IN PSYCHIATRIC GENETICS: WHETHER, WHEN, AND HOW TO IMPLEMENTAlex RamseyLaura BierutLaura BierutElsevier BVEuropean Neuropsychopharmacology
Polygenic risk scores: how much do they add?Keywords clinical utilitycoronary artery diseaseLDL cholesterolpolygenic risk scorerisk predictionPURPOSE OF REVIEW :Current methods to assess genetic risk of familial hypercholesterolemia and coronary artery disease (CAD) focus on testing monogenic mutations in ...
Improving Polygenic Risk Scores forCoronary Artery Disease: What Helps and by How Much?doi:10.1016/j.jacbts.2023.10.005biomarkerscoronary heart diseaseFinnGengenome-wide association studiespolygenic risk scoresEzimamaka C. Ajufo MDKrishna G. Aragam MD, MS...
5:45 PM THE GENETIC ARCHITECTURE OF SCHIZOPHRENIA: HOW DO CNVS AND POLYGENIC SCORES CONTRIBUTE TO DISEASE RISK? - Schizophrenia Research
We sought to explore individuals' motivations for using their direct-to-consumer genetic testing data to generate polygenic risk scores (PRSs) using a not-for-profit third-party tool, and to assess understanding of, and reaction to their results. Using a cross-sectional design, users of Impute...
Specifically, we use PRS-CS to calculate PGS from the latest available GWAS summary statistics and examine variations in PGS R across overlapping intersections of sex, age, deprivation, income, education, smoking, and drinking behavior. Results As hypothesized, R from PGS exhibited substantial ...