Polygenic risk scoresPooled cohort equationLifestylePurpose of Review The potential of polygenic risk scores (PRS) to improve atherosclerotic cardiovascular disease (ASCVD) risk assessment and management has stoked significant interest in their incorporation into clinical management. The goal of this review...
The study authors imagine a day when people could be given a "polygenic risk score" which considers their gene variants and interactions to provide personalized recommendations for quitting. For instance, preliminary studies have already suggested that people with high-risk genotypes in the CHRNA5 reg...
To calculate both statistic measures, a phenotypic correlation matrix for each MVMR test had to be constructed. This was done by applying the method for phenotypic matrix construction from GWAS summary data, available from metaCCA80 R package. This is an alternative approach to using individual-lev...
A more powerful method was recently developed that sums up thousands of the genetic markers found in the GWAS studies to instead calculate a genome-wide "polygenic score". This scoreis now being used, with increasing levels of accuracy, to predict variance in a trait, such as school achievemen...
Polygenic risk scores: how much do they add?Keywords clinical utilitycoronary artery diseaseLDL cholesterolpolygenic risk scorerisk predictionPURPOSE OF REVIEW :Current methods to assess genetic risk of familial hypercholesterolemia and coronary artery disease (CAD) focus on testing monogenic mutations in ...
Polygenic risk scores (PRS) are promising for identifying common variant‐related inheritance for psychiatric conditions but their integration into clinical practice depends on their clinical utility and psychiatrists'' understanding of PRS. Our online survey explored these issues with 276 professionals ...
Risk predictionResearch methodsPurpose of Review To explain how the intended use of polygenic risk scores (PRSs) in healthcare guides the design and evaluation of prediction studies.doi:10.1007/s40471-019-00203-7Forike K. MartensA. Cecile J.W. Janssens...
PUSHING THE ENVELOPE WITH POLYGENIC RISK SCORES IN PSYCHIATRIC GENETICS: WHETHER, WHEN, AND HOW TO IMPLEMENTAlex RamseyLaura BierutLaura BierutElsevier BVEuropean Neuropsychopharmacology
POLYGENIC RISK SCORES FOR PSYCHIATRIC DISORDERS ARE ALREADY ACCESSIBLE TO THE PUBLIC: HOW DO WE PROMOTE POSITIVE OUTCOMES AND MITIGATE POTENTIAL FOR HARM?doi:10.1016/j.euroneuro.2021.07.053Jehannine AustinElsevier BVEuropean Neuropsychopharmacology
5:45 PM THE GENETIC ARCHITECTURE OF SCHIZOPHRENIA: HOW DO CNVS AND POLYGENIC SCORES CONTRIBUTE TO DISEASE RISK? - Schizophrenia Research