Eight categories of metaphors that women used surrounding BRCA gene testing were evident in the data, including those related to (a) knowledge is power; (b) gambling; (c) a journey; (d) a rollercoaster; (e) battle, disaster, or wreckage; (f) Pandoras box or a can of worms; (g) ...
How similar is one's DNA to their parents and siblings? DNA Inheritance: Offspring receive half of their DNA from their mother and half of their DNA from their father. This happens when a sperm cell (from the father) meets the egg cell (from the mother) and fertilization occurs. The sp...
This medication attaches to the Trop-2 protein on breast cancer cells, taking a chemo drug directly to them. Too much Trop-2 protein helps breast cancer cells grow and spread quickly. This drug can be used to treat triple negative breast cancer after other chemotherapies have been tried. Tal...
However, this is a formal principle and leaves much to be determined. In discussions of discrimination in insurance based on genetic information, disagreement, and frequently, mutual incomprehension, mark exchanges be- tween those committed to actuarial fairness and those com- mitted to the view of...
[15]. This type of study would require the use of multi-color flow cytometry [16] and also intersects with microbiome [17] datasets, but it can be now accomplished with much higher accuracy due to the rise of single-cell RNA-sequencing (scRNA-seq) and single-cell ATAC (assay for ...
Most mammalian species have heteromorphic sex chromosomes in males, except for a few enigmatic groups such as the mole voles Ellobius, which do not have the Y chromosome and Sry gene. The Ellobius (XX ♀♂ ) system of sex chromosomes has no analogues amo
Precision medicine is much more targeted. Over years of research, scientists have learned more about the genetics behind how diseases start and how they behave. Many diseases are linked to gene changes. Thanks to the Human Genome Project, researchers now have a map of all the genes in the hu...
breast cancer; gene panels; TP53; variant; interpretation; Li-Fraumeni syndrome; heritable TP53-related cancer syndrome1. Introduction The development of cancer multi-gene panels has resulted in an exponential increase of TP53 testing in patients with breast cancers, as TP53 is included in most of...
The remaining 99% of the total DNA sequence, colloquially called “dark matter of the DNA” is much less characterised, but also holds disease-relevant changes [10]. Multiple types of RNA produced from those regions regulate gene expression at many levels and this knowledge dramatically changed ...
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