The article reports on the findings by researchers from the University of Rochester School of Medicine that BRCA 1/2 genetic testing of women at high risk of carrying the BRCS 1 or 2 gene mutations, and treatment of those who test positive, seems to be cost effective compared with no ...
Cost-effectiv... ML Holland,A Huston,K Noyes - 《Value in Health》 被引量: 52发表: 2009年 Mutations of the BRCA1 and BRCA2 genes and the possibilities for predictive testing Two cancer susceptibility genes, BRCA1 on chromosome 17q12-21 and BRCA2 on chromosome 13q12-13, are thought to...
The test cost was calculated using the charge for full BRCA1/2 gene sequencing (Myriad Genetics, Inc.) multiplied by a Medicare-based cost-to-charge ratio. Counselors spent an average of 4.2 h providing genetic counseling for women at risk of having a susceptibility mutation. Genetic counseling...
[Abstract]Germline mutations inBRCAgenes (includingBRCA1/2) are the major risk factors for hereditary tumors including breast and ovarian cancer. Population basedBRCAgene screening, particularly in high-risk individuals with a ...
[摘要]BRCA基因(包括BRCA1和BRCA2)的胚系突变是家族性乳腺癌、卵巢癌等肿瘤的核心风险因素。在人群中,特别是已有肿瘤家族史的高危人群中,BRCA基因检测可以发挥预防性管理作用,有助于降低此类遗传性疾病的死亡率和社会危害。近年来基于二代测序技术的BRCA胚系突变检测方案逐步落地,检测可及性不断增强。为了进一步规范相...
testing in the population, including screening scenarios, technical approaches, quality control, result interpretation and reporting, as well as genetic counseling. Through multidisciplinary discussions and Delphi questionnaire survey "expert consensus on population-based BRCA germline mutation screening in ...
The prospect of germline testing for all As the cost of sequencing decreases and knowledge advances, there is an ongoing debate about whether multi-gene cancer panels should be used on broader populations, and what those populations might look like. ...
Patients with a higher likelihood to develop BRCA 1 or BRCA 2 mutations are slipping through the cracks, making testing for these mutations a vital part of any breast cancer treatment plan. It’s important for their providers to test for BRCA1 and BRCA2 gene mutations in patients with...
Genet Med advance online publication 14 April 2016 Key Words: BRCA; breast cancer; cost-effectiveness; health-care programs; systematic review; According to the Centers for Disease Control and Prevention, breast cancer susceptibility gene (BRCA) mutation testing is one of the few genetic applications...
Read more:As revenue falls, a pioneer of cancer gene testing slams rivals with overblown claims Really? Genetic counselors, physicians, and BRCA-positive women have lit up social media attacking the study. For one thing, the conclusion that a large majority of the Angelina-effect women teste...