result interpretation and reporting, as well as genetic counseling. Through multidisciplinary discussions and Delphi questionnaire survey "expert consensus on population-basedBRCAgermline mutation screening in China (2024 edition)" w...
1999 . A highly accurate, low cost test for BRCA1 mutations . J Med Genet 36 : 747 – 753 .van Orsouw NJ, Dhanda RK, Elhaji Y, et al. A highly accurate, low cost test for BRCA1 mutations. J Med Genet. 1999;36(10):747-753....
检索时限起始于1990年1月,截至2023年8月,英文文献检索词主要包括BRCA1/2、hereditary breast cancer、hereditary ovarian cancer、germline mutation、screening test、population screening、BRCAscreening、cancer risk assessment、cancer susceptibility、genome sequencing、variant classification、genetic counseling、quality...
BRCA test results fall into three categories: positive, negative or variant of uncertain significance (VUS). A positive result means the person carries a BRCA mutation that increases their risk of cancer. A negative result means no BRCA mutation was found, but doesn’t rule out all cancer ris...
Is BRCA Mutation Testing Cost Effective for Early Stage Breast Cancer Patients Compared to Routine Clinical Surveillance? The Case of an Upper Middle-Income... K Keat,Lim,S Yee,... - 《Applied Health Economics & Health Policy》 被引量: 0发表: 2018年 Psychological impact of receiving a BRCA...
In both cases the probability of identifying a BRCA gene mutation was 10% and no FM had been characterized.25 Prophylactic surgery was offered to BRCA mutation-positive women. This strategy was cost-effective ($5,000/QALY) when compared with no intervention. Using data from a sensitivity ...
Cost-effectiveness of population-based BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, PALB2 mutation testing in unse- lected general population women. JNCI J Natl Cancer Inst. 2018;110:1–12. https://doi.org/10.1093/jnci/djx265 Trends in BRCA testing and socioeconomic deprivation 1359 12. ...
Objective To examine the effect of tamoxifen therapy, bilateral prophylactic oophorectomy (PO), prophylactic contralateral mastectomy (PCM), and combinations of these strategies on life expectancy for women with unilateral breast cancer and a BRCA1 or BRCA2 gene mutation. Design and Setting Decision ...
Indications for increased risk of having a genetic mutation associated with breast cancer is shown in Box 1. There is a cost related to testing and a cost related to the preventive approaches. Therefore, in low-income countries the appropriate counseling is not offered to the patients [71]. ...
If one of your parents has already tested positive for the BRCA1 or 2 gene mutation, then you have a 50/50 chance of testing positive as well. If you end up being one of the unlucky ones in this particular coin toss, then what?