Here, we introduce the protein structure idealization problem. We focus on the protein backbone structure idealization. We describe a fast O(nm/??) dynamic programming algorithm to find an idealized protein backbone structure that is approximately optimal according to our scoring function. The scoring...
2c). However, crystal structures of multi-domain FliG31,35,38 required substantial interdomain adjustment to match the cryoEM structure (Extended Data Fig. 4a–f). In addition, past work supports FliG as a three-domain protein38; however, FliG contains five domains when it is assembled into...
1. Which organelle is a cell organelle composed of RNA and protein? 2. What role does it play in protein synthesis? Describe the structure of ribosomes and how they are assembled. What do you consider the most important structure or organelle in a living cell, and why? Identify the organe...
In proteins, the optimal residue at any position is determined by its structural, evolutionary, and functional contexts—much like how a word may be inferred from its context in language. We trained masked label prediction models to learn representations of amino acid residues in different contexts....
and forecasting problems. Some of the networks require dynamic backpropagation for computing the gradients and others do not. As a user, you do not need to decide whether or not dynamic backpropagation is needed. This is determined automatically by the software, which also decides on the best ...
The independence of the final, folded native structure of a water-soluble globular protein—after either in vivo or in vitro folding—on the initial state of its chain shows that the native protein structure is—in accordance with the Anfinsen's “thermodynamic hypothesis”—the most stable of ...
To make a protein of 100 amino acids, a messenger RNA must be longer than 300 nucleotides, and it is therefore not surprising that nature takes advantage of the enormous structure-forming potential of RNA. What we know today about RNA structure may be only the tip of an iceberg. RNA ...
The discovery added further evidence to the idea that obesity was biologically determined, and more specifically to the concept of a “set point” when it comes to weight—a predetermined weight, fat mass, or other measurable physiological characteristic that the body will defend. Appetite is the...
The primary structure of proteins is the linear sequence of amino acids linked by peptide bonds. When the amino acids in the linear sequence form...Become a member and unlock all Study Answers Start today. Try it now Create an account Ask a questi...
Their popularity began to rise with GANs (Generative Adversarial Networks), which are widely applied in computer vision (image and video processing, generation, and prediction), as well as in various science and business-related fields, such as crystal structure synthesis, protein engineering, and ...