Here, we introduce the protein structure idealization problem. We focus on the protein backbone structure idealization. We describe a fast O(nm/??) dynamic programming algorithm to find an idealized protein backbone structure that is approximately optimal according to our scoring function. The scoring...
2c). However, crystal structures of multi-domain FliG31,35,38 required substantial interdomain adjustment to match the cryoEM structure (Extended Data Fig. 4a–f). In addition, past work supports FliG as a three-domain protein38; however, FliG contains five domains when it is assembled into...
In proteins, the optimal residue at any position is determined by its structural, evolutionary, and functional contexts—much like how a word may be inferred from its context in language. We trained masked label prediction models to learn representations of amino acid residues in different contexts....
1. Which organelle is a cell organelle composed of RNA and protein? 2. What role does it play in protein synthesis? Describe the structure of ribosomes and how they are assembled. What do you consider the most important structure or organelle in a living cell, and why? Identify the organe...
and forecasting problems. Some of the networks require dynamic backpropagation for computing the gradients and others do not. As a user, you do not need to decide whether or not dynamic backpropagation is needed. This is determined automatically by the software, which also decides on the best ...
The independence of the final, folded native structure of a water-soluble globular protein—after either in vivo or in vitro folding—on the initial state of its chain shows that the native protein structure is—in accordance with the Anfinsen's “thermodynamic hypothesis”—the most stable of ...
DNA carries all the information for your physical characteristics, which are essentially determined by proteins. DNA contains the instructions for making a protein. In DNA, each protein is encoded by a gene (a specific sequence of DNA nucleotides that specify how a single protein is to be made...
636 Predicting how proteins fold up IN current and pending publications there are signs of a new, more ambitious phase in the struggle to predict the biologically active conformation of a protein from its covalent structure. Certainly there is much incentive for ambitious investigations in this ...
The discovery added further evidence to the idea that obesity was biologically determined, and more specifically to the concept of a “set point” when it comes to weight—a predetermined weight, fat mass, or other measurable physiological characteristic that the body will defend. Appetite is the...
Their popularity began to rise with GANs (Generative Adversarial Networks), which are widely applied in computer vision (image and video processing, generation, and prediction), as well as in various science and business-related fields, such as crystal structure synthesis, protein engineering, and ...