The use of pharmaceuticals for the treatment of pets is connected with discharge directly into the environment. The estimation (load) of this source has never been presented and is hard to calculate; some may say that this is a minor part of the total mass of pharmaceuticals introduced into t...
In preclinical studies, researchers at Bolt have demonstrated profound antitumor efficacy for BDC-1001, the company’s lead HER2-targeted ISAC therapeutic program when administered as a monotherapy. Treatment results in activation of the innate immune system that subsequently generate...
Intergroup Trial of Adjuvant Chemotherapy in Adenocarcinoma of the Stomach (ITACA-S) trial: Comparison of a sequential treatment with irinotecan (CPT-11) p... Background: The long-term survival in hepatocellullar carcinoma (HCC) patients after transarterial chemoembolization (TACE) remains dismal due...
(t1⁄2) of free aflibercept in plasma was approximately 5 to 6 days after I.V. administration of doses of 2 to 4 mg⁄kg aflibercept [41]. Initially intravenous aflibercept was tried for AMD [42]. It is approved in combination with 5–fluorouracil, leucovorin, and irinotecan (FOLFIRI)...
The combination of irinotecan and tankyrase inhibitors diminishes the proliferation and growth of cancer cells via downregulation of the c-kit [232]. The microRNA (miR)-664, as an onco-suppressor, reduces the expression of the c-kit to suppress the proliferation and invasion of cancer cells [...
CRTH is administered to specific patients who have not responded partially to neoadjuvant chemotherapy before undergoing surgical resection. Our recommendations for adjuvant treatment are the same as for R-PDAC. Drawing on published studies, guidelines and our expertise, we have created a diagram ...
A retrospective analysis showed that the exposure to all three cytotoxics (fluoropyrimidines, oxaliplatin and irinotecan), in various sequences, produce longer survival [9]. The chemotherapeutic regimen alternative to the combination administered during first-line therapy should be offered to patients wit...
To date, drugs of plant origin, or their derivates (paclitaxel, vinblastine, vincristine, vinorelbine, etoposide, camptothecin, topotecan, irinotecan, and omacetaxine), are very important in the therapy of malignancies and they are included in most chemotherapeutic regimes. To date, 391,000 plant ...