The recommended initial dose of irinotecan in the US is 125 mg/m2administered as a 90-minute intravenous infusion. The recommended treatment regimen is 1 weekly dose for 4 weeks followed by a 2-week drug-free interval. This 6-week regimen may be repeated; subsequent doses should be adjusted...
CPT-11 (180 mg/m2; 30-minute intravenous infusion) was administered on day 1, simultaneously with leucovorin administration. This cycle was repeated every 2 weeks. Complete response was achieved in 4 patients (8%) and partial response in 19 (37%) (overall response rate: 45%; 95% CI: ...
Administer Irinotecan Hydrochloride Injection, USP as a 90-minute intravenous infusion. The currently recommended regimens are shown in Table 3. A reduction in the starting dose by one dose level of Irinotecan Hydrochloride Injection, USP may be considered for patients with any of the following cond...
Methods Patients received CPT-11 60mg/m2 as a 90-minute infusion,LV 100mg/m2 iv infusion for 2h and fluorouracil 500mg/m2 iv infusion for 6h on days 1,8 and 15 with 4 week as a cycle,with 6 cycles as a maximum. Tumor assessment was done every 2 cycles,including the efficacy,...
Infuse diluted solution over a period of 90 minutes; more rapid infusion rates may increase the likelihood of cholinergic symptoms. (See Diarrhea under Cautions.)IV Administration of Liposomal IrinotecanDo not use in-line filters.Discard any unused solution....
Administer CAMPTOSAR as a 90-minute intravenous infusion followed by LV and 5-FU. The currently recommended regimens are shown in Table 1. A reduction in the starting dose by one dose level of CAMPTOSAR may be considered for patients with any of the following conditions: prior pelvic/abdomi...
They received six 28-day cycles of oxaliplatin (85 mg/m2 in a 2-h infusion on days 1 and 15) and irinotecan (80 mg/m2 in a 30-minute infusion on days 1, 8 and 15 immediately following oxaliplatin). RESULTS: Thirteen patients (39%) completed treatment. The most common grade Ill-...
A clinical study has been conducted since August 2001 to investigate whether chemotherapy with CPT-11/l-LV/ 5-FU/UFT could be an effective regimen for advanced or recurrent colorectal cancer. The chemotherapy consisted of CPT-11 30 mg/m2 iv, as a 120-minute infusion, followed by l-LV 30...
Irinotecan (Fig. 5.1 also called CPT-11 or 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin) is a semisynthetic analog of the natural alkaloid camptothecin. It was first approved in Japan in 1994 for small-cell lung cancer and hematologic malignancies, followed by approvals ...
The Texas Children’s Cancer Center researchers are currently conducting a phase I study testing irinotecan as a 90-minute infusion given weekly for 4 weeks with cycles repeating every 6 weeks. Patients are stratified according to level of pretreatment. ...