High-dose melphalan and autologous stem cell transplantation (HDM) is an effective treatment for systemic amyloid light chain (AL) amyloidosis but the eligibility criteria exclude many patients with this disorder. The aim of this study was to determine appropriate treatment strategies for systemic AL ...
Amyloidosis is a buildup of abnormal proteins in your tissues and organs. Explore the symptoms and treatments of this rare but serious disease. View now 10 Ways Multiple Myeloma Is Different for Black and Hispanic People Medically reviewed byShruthi Non May 26, 2024Written byAlyssa Anderson ...
Amyloidosis is a rare group of diseases characteri Leung,Nasr,H S.,... - 《Blood the Journal of the American Society of Hematology》 被引量: 0发表: 2012年 Histological outcome in patients with chronic hepatitis C given a 60-week interferon alfa-2b treatment course Forty patients with chroni...
in a way that prevents it from deviating from this natural, functional form into the amyloid state. TTR's natural, functional form is a "tetramer" made from four copies of the protein. Amyloidosis occurs when these tetramers come apart and the individual TTR proteins...
Amyloidosis relapsing after autologous stem cell transplantation treated with bortezomib: normalization of detectable serum-free light chains and reversal of tissue damage with improved suitability for transplant. Haematologica 2010; 95: 519–521. Article Google Scholar Lamm W, Willenbacher W, Lang A,...
A feared acute complication in sJIA is macrophage activation syndrome (MAS) that affects around 10 % of patients and goes along with high fever, cytopenia, impaired liver function, coagulopathy and considerable mortality [26]. Long-term complications also include AA amyloidosis [27, 28]. Although...
Survey for evaluation of AL amyloidosis Bleeding time, APTT, PT Cryoglobulins, cold agglutinins Serum viscosity, fundoscopy: symptoms of hyperviscosity HLA typing: in case allo-SCT is considered BUN indicates blood urea nitrogen; CRP, C-reactive protein; MRI, magnetic resonance imaging; CT, comp...
29 For instance, subendocardial or transmural LGE with a vascular distribution points towards ischemia, while global subendocardial LGE is associated with conditions like amyloidosis, systemic sclerosis. Subepicardial or patchy LGE is linked to myocarditis, sarcoidosis, Fabry disease, or Chagas ...
Through focused efforts in health tech innovation, Pfizer is committed to advancing how we detect individuals at risk of transthyretin cardiac amyloidosis (known as ATTR-CM) – a rare, progressive, and underdiagnosed cause of heart failure.2,3 We are advancing AI in healthcare by supporting cutti...
Rousseau F, Schymkowitz J, Serrano L: Protein aggregation and amyloidosis: confusion of the kinds?. Curr Opin Struct Biol. 2006, 16: 118-126. 10.1016/j.sbi.2006.01.011. Article CAS PubMed Google Scholar Lopez Dela Paz M, Serrano L: Sequence determinants of amyloid fibril formation. Proc...