(2011) How to treat patients with systemic amyloid light chain amyloidosis? Comparison of high-dose melphalan, low-dose chemotherapy and no chemotherapy in patients with or without cardiac amyloidosis. Clinical and Experimental Nephrology 15 , 486-492 /...
3,4 Nonamyloid fibrillary glomerulonephritis should not be considered as MGRS because it is nearly always characterized by polyclonal IgG deposits without a detectable clonal B-cell disorder.5,6 In MGRS, deposits of different ultrastructural patterns derived from the same MIg can occur. For instance...
BUN indicates blood urea nitrogen; CRP, C-reactive protein; MRI, magnetic resonance imaging; CT, computed tomography; 18F-FDG-PET, 18F-fluorodeoxyglucose positron emission tomography; AL, amyloid light chain; APTT, activated partial thromboplastin time; and PT, prothrombin time. * FISH is preferably...
Both medications can help treat cognitive symptoms by reducing amyloid plaques in the brain and are administered intravenously (into a vein).6 These treatments are intended to slow neurodegeneration and disease progression. In January 2024, Biogen, the maker of Aduhelm, announced that it would ...
How do I decide between Leqembi and Kisunla? Will insurance cover Kisunla treatment? How well does Kisunla work? What common side effects were seen in Kisunla studies? The Kisunla label carries a Boxed Warning for amyloid-related imaging abnormalities (ARIA), such as edema (ARIA-E), micro...
Leqembi has been shown to successfully reduce amyloid plaques in the brain. (It’s actually the second drug shown to do this; the first one was Aduhelm.) Amyloid plaque is a substance that may lead to tissue loss in parts of the brain related to memory, thinking, and learning. It’s ...
Manenti L, Tansinda P, Vaglio A . Eprodisate in amyloid A amyloidosis: a novel therapeutic approach? Expert Opin Pharmacother 2008; 9: 2175–2180. Article CAS Google Scholar Ratner M . Spotlight focuses on protein-misfolding therapies. Nat Biotechnol 2009; 27: 874. Article CAS Google Scho...
aWe also examined whether O4-generated Aβ42 aggregates can be detected with the conformation-specific antibody B10, which preferentially recognizes amyloid fibrils but does not bind to monomers or small oligomers. 我们也审查O4引起的Aβ42聚集体是否可以查出与相应一致具体抗体B10,优先地认可淀粉质原纤维...
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OBJECTIVE: , a secretory of beta-cells, is the constituent of islet amyloid, which is characteristic of , and changes in in response to therapies may influ... J Rachman,MJ Payne,JC Levy,... - 《Diabetes Care》 被引量: 815发表: 1998年 Review article: drug interactions with agents used...