Transduction of guidance cues may also mobilise the second messenger inositol triphosphate (IP3) and subsequent calcium release from the ER via IP3 receptors in a process known as IP3-induced calcium release (IICR) (reviewed in recently in Tojima et al., 2011). These mechanisms are important ...
Calcium Calmodulin CNS Glioblastoma Stem cells Sorry, something went wrong. Please try again and make sure cookies are enabledReferences [1] B.A. Sherrod, N.T. Gamboa, C. Wilkerson, H. Wilde, M.A. Azab, M. Karsy, R.L. Jensen, S.T. Menacho Effect of patient age on glioblastoma pe...
The mechanisms underlying the growth of fungal hyphae are rooted in the physical property of cell pressure. Internal hydrostatic pressure (turgor) is one of the major forces driving the localized expansion at the hyphal tip which causes the characteristic filamentous shape of the hypha. Calcium gradi...
D2 dopamine receptors in striatal medium spiny neurons reduce L-type Ca2+ currents and excitability via a novel PLC[beta]1-IP3-calcineurin-signaling cascade. J Neurosci. 2000;20:8987–95. Article CAS PubMed PubMed Central Google Scholar Yan Z, Song WJ, Surmeier J. D2 dopamine receptors ...
Over the last two decades, the understanding of how dysregulated ion channels and transporters are involved in carcinogenesis and tumor growth and progression, including invasiveness and metastasis, has been increasing exponentially. The present review s
(IP3) receptors to mobilize calcium from the ER into the cytosol128,129,130. Although calcium release does not seem to be directly linked to facilitating viral morphogenesis in these examples, they nonetheless highlight the widespread use of viral components to cause calcium efflux from the ER ...
S. TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive d-serine release. J. Neurosci. 33, 10143–10153 (2013). CAS PubMed PubMed Central Google Scholar Sherwood, M. W. et al. Astrocytic IP3Rs: contribution to Ca2+ signalling and ...
When compared to the orders of magnitude increase observed in known models of lipid peroxidation-induced cell death115,116, these comparatively small increases in LPO markers suggest that LPO does not occur at a high enough level to directly cause cell death in APAP hepatotoxicity. 3.5.2. ...
Even if the increase in ATP is modest, it should be considered that small differences could be sufficient to restore a healthy state due to the threshold effect [69,70]. Furthermore, the positive molecules could induce the metabolic shift from glycolysis to OXPHOS. This is particularly valuable...
Hagenston and colleagues showed that glutamate acting on mGluR mediates an IP3-dependent wave of Ca2+ that activates SK channels responsible for AHP [86]. As TRPC channels are calcium-permeable, they could contribute to AHP. Interestingly, Neuner et al. developed a targeted proteomics approach and...