MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression at a post-transcriptional level in virtuallyall eukaryotic organisms a... L Dölken,S Pfeffer,UH Koszinowski - 《Virus Genes》 被引量: 60发表: 2009年 Assigning Intonational Features in Synthesized Spoken Directi...
I don’t really care about the column order. The only solution I can think of is to add the ID column to each csv file then loop through them callingmerge()several times. Is there a more elegant approach? 8down voteaccepted My understanding is that you need to extract the ID from the...
Given the indication that several mechanisms are in place to regulate caspase activation and apoptosis post-MOMP, the next question that arises is why a cell would need to commit resources to do so once mitochondrial integrity has been compromised. As previously mentioned, it appears that a speci...
aImportantly, these constructs regulate gene expression up to threefold more effectively than analogous molecular miRNAs delivered using a commercial co-carrier Dharma-FECT. 重要地,这些修建比使用一个商业co载体被提供的近似分子miRNAs更加有效地调控基因表达由三倍决定Dharma-FECT。 [translate] aTax authorities...
In this paper we develop a new method that can reveal miRNAs able to regulate, in a coordinated way, networks of gene pathways. We applied the method to subtypes of breast cancer. The basic idea is the identification of pathways significantly enriched with differentially expressed genes among the...
There is also evidence of abnormalities in the epigenetic regulation of gene expression in CFS patients diagnosed via narrow criteria, most notably in gene promoter methylation patterns and elevation of microRNAs (miRNAs) involved in the regulation of the immune system (Brenu et al.2014a; de Vega...
(the gene for retinoic acid-related orphan nuclear hormone receptor C) likely underlies its ability to downregulate the production of IL-17 [128,129]. INF-β therapy also downregulates the production of PICs by dendritic cells and upregulates the production of IL-12 and IL-23, hence shifting...
The mechanisms underpinning this association are not understood, but they may be connected to altered expression of miR-486.ANK1is a host gene for miR-486 [162] which in turn is a source of two mature miR-486 miRNAs, namely, miR-486-3p and miR-486-5p [163]. Importantly,ANK1hypermethyl...
There is evidence that GSK-3α enhances the activity of the γ-secretase complex [277] and may act to downregulate the activity of α-secretase [280]. There is also accumulating evidence, albeit in vitro, demonstrating that ApoE4 increases GSK3B expression, potentially leading to the ...
In summary, viruses employ one or multiple ways to down-regulate host gene expression at the level of mRNA while promoting stability of the viral RNA. 3. Shutting-Down Cellular Small Non-Coding RNAs The host shut-off effect is a phenomena used by viruses to silence the expression of host ...