Nuclear functions of mammalian MicroRNAs in gene regulation, immunity and cancer. Mol Cancer. 2018;17(1):64. Published 2018 Feb 22.5. Felekkis K, Touvana E, et al. microRNAs: a newly described class of encoded molecules that play a role in health and disease. Hippokratia 14(4), 236–...
如上所述:miRNA不仅可以在细胞内(local)发挥作用,还可以循环miRNA的形式进行远程通讯(cross-cell、tissue or organ regulation),甚至可以穿过胎盘调节子代的发育(cross-generation regulation)。而在2012年的一项经典研究,更是揭开了miRNA另外一项...
3. Rupaimoole R, Slack FJ. MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov. 2017;16(3):203-222. 4. Liu H, Lei C, et al. Nuclear functions of mammalian MicroRNAs in gene regulation, immunity and cancer. Mol Cancer. 2018...
3.Rupaimoole R, Slack FJ. MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov. 2017;16(3):203-222. 4.Liu H, Lei C, et al. Nuclear functions of mammalian MicroRNAs in gene regulation, immunity and cancer. Mol Cancer. 2018;17...
3. Rupaimoole R, Slack FJ. MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov. 2017;16(3):203-222. 4. Liu H, Lei C, et al. Nuclear functions of mammalian MicroRNAs in gene regulation, immunity and cancer. Mol Cancer. 2018...
[28] keda S, He A, Kong SW,et al. MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes[J] Mol Cell Biol, 2009, 29(8): 2193-204. [29] Elia L, Contu R,Quintavalle M,et al. Reciprocal regulation of microRNA-1 and insulin-like growth...
Conjunctival epithelium of patients with conjunctival chalasis (n=3) served as the control. We confirmed the down- and up-regulation of miRNA of interest by quantitative real-time polymerase chain reaction (RT-PCR) assays using the conjunctival epithelium from 6 SJS/TEN with SOC patients and 7...
3. Rupaimoole R, Slack FJ. MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov. 2017;16(3):203-222. 4. Liu H, Lei C, et al. Nuclear functions of mammalian MicroRNAs in gene regulation, immunity and cancer. Mol Cancer. 2018...
[9];而且对免疫细胞和免疫分子具有调控作用,当其表达失调时可通过免疫调控参与多种妊娠并发症,如miR-103通过信号转导与转录激活因子(signal transducer and activator of transcription,STAT)1/干扰素调节因子1(interferon regulatory factor 1,IRF1)信号通路...
Fig. 1 Gnai2 is a novel target gene of miR-221-3p. (A) A 30 UTR sequence of Gnai2 targeted by miR-221-3p. (B) GNAI2 is significantly downregulated in primary hepatocytes isolated from fibrotic liver tissues in vivo. AAV TuD injection leads to upregulation of Gnai2 (C) mRNA and...