inhibiting the expression of host genes.It can also be combined with genes that inhibit host gene expression to upregulate host gene expression.The discovery of intron microRNA not only provides more insights into the function of introns,but also helps to understand the function of host gene ...
Typically, miRNAs downregulate the target expression by binding to the 3′ UTR of mRNAs. However, recent studies have demonstrated that miRNAs can upregulate target gene expression, but its mechanism is not fully understood. We previously found that G-rich RNA sequence binding protein (GRSF1) ...
Small Interfering RNAs (siRNA) are double-stranded, non-coding RNAs that inhibit gene expression through RNA interference. They interfere with gene expression by degrading mRNA and preventing the translation of proteins. siRNAs form from long double-stranded RNAs with the assistance of Dicer. Once fu...
microRNAs (miRNAs) play an important role in carcinogenesis. Typically, miRNAs downregulate the target expression by binding to the 3′ UTR of mRNAs. However, recent studies have demonstrated that miRNAs can upregulate target gene expression, but its mec
Here, we found that MYOD transcription factor can upregulate miR-223 expression by binding to an E-box region of the gga-miR-223 gene promoter during avian myoblast differentiation. IGF2 and ZEB1 are two target genes of miR-223. The target inhibition of miR-223 on IGF2 and ZEB1 are ...
Glucose and oxygen deprivation during ischemia is known to affect the homeostasis of the endoplasmic reticulum (ER) in ways predicted to activate the unfolded protein response (UPR). Activation of UPR signalling due to ER stress is associated with the de
ensuring biologically relevant results. mirna functional studies ambion pre-mir mirna precursor libraries and anti-mir mirna inhibitor libraries address the needs of researchers seeking to upregulate and/or downregulate the levels of all known mirnas to study endogenous or reporter ...
MALAT1 acted as a sponge of miR-206 to upregulate VEGFA phrase, therefore marketing the differentiation of BM-MSCs into ECs. Moreover, MALAT1 silencing in vivo damaged the repairing effect of BM-MSCs on erectile dysfunction. Collectively, MALAT1 facilitates BM-MSCs differentiation into ECs via ...
作者: P Shapshak 展开 摘要: The article discusses the involvement of microRNA (miRNA) in the neurological disease, Multiple Sclerosis (MS). It mentions that MS has been regarded as a neurodegenerative disease associated with defects in the blood-brain barrier (BBB). It reveals that recent ...
miRNA degrades or inhibits mRNA translation by matching genes targeting the 3' UTR region of mRNA, thereby regulating its gene expression. There are many miRNA response elements on circRNA, which can adsorb miRNA by covalently binding with these response elements and upregulate the downstream target...