HowdolncRNAsregulatetranscriptionlncRNA如何调节转录 系统标签: lncrnaslncrnatranscriptionregulate转录rnas GENEEXPRESSIONCopyright©2017 TheAuthors,some rightsreserved; exclusivelicensee AmericanAssociation fortheAdvancement ofScience.Noclaimto originalU.S.Government Works.Distributed underaCreative CommonsAttribution No...
(lncRNAs) have been shown to regulate gene expression in cis, it remains unclear whether lncRNAs can directly regulate transcription in trans by interacting... KW Vance,SN Sansom,S Lee,... - 《Embo Journal》 被引量: 167发表: 2014年 Identification of a long non-coding RNA-associated RNP co...
Plants develop both short-term and transgenerational memory of drought stress through epigenetic regulation of transcription for a better response to subsequent exposure. Abstract Recurrent spells of droughts are more common than a single drought, with intermittent moist recovery intervals. While the detrim...
Over the last two decades, the understanding of how dysregulated ion channels and transporters are involved in carcinogenesis and tumor growth and progression, including invasiveness and metastasis, has been increasing exponentially. The present review s
DECODING THE NON-CODING Among the non-coding RNAs (ncRNAs), a group that includes siRNAs, miRNAs, circularRNAs, and piRNAs, there is a heterogeneous group called long non-coding RNAs (lncRNAs)— RNA molecules longer than 200 nucleotides that do not code for proteins. LncRNAs are,...
While this has so far been used to study DNA viruses’ transcription, it might also prove useful to study replication of RNA viruses. We are still lacking a global picture of RNA modifications that are present in viral RNAs, and more importantly, we need to determine their exact contribution...
With specific regard to bone cells, SCFA have been demonstrated to promote bone formation by stimulating osteogenic transcription factors such as Runx2 [70]. Especially, acetate and propionate have been found to up-regulate early osteogenic markers, such as alkaline phosphatase (ALP) [55]. In ...
Upstream mediators target these molecular pathways to regulate angiogenesis. The steroid receptor coactivator (Src) and focal adhesion kinase (FAK) are tyrosine kinases capable of controlling angiogenesis. The EGFR effect on migration relies on FAK [238]. Src has been displayed to induce angiogenesis ...
Consequently, oligonucleotides targeting lncRNAs, which interfere with regulation in the tissues of an arthritic joint, can provide new therapeutic strategies triggering epigenetic factors involved in joint inflammation [171,174]. It is important to note that since oligonucleotide therapy is based on a ...
Thus, these novel candidate lncRNAs may also play a key role in neuropsychiatric disorders. Later on, many studies took advantage of the combined use of whole transcriptomic and gene network analysis using the iPSC-based modelling of idiopathic and non-syndromic ASD [62,63], rare developmental ...