In this computational work, several model cell-binding peptides with a minimal cell-adhesive Arg鈥揋ly鈥揂sp sequence are investigated in the bulk as well as immobilised on a soft surface. For this reason, a combination of density functional theory and all-atom MD simulations is applied. The...
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Among the physicochemical cues in the cellular microenvironment that orchestrate cell processes, the different levels of curvature in the extracellular matrix and intrinsic to the tissues play a pivotal role in the spatiotemporal control of key cellular
The experiments conducted by the research team found that bound water on the surface of the cotton fibers created a "capillary adhesion" of the tiny fibers to each other, creating stiffness in the fabric when these little strings glued together. "The bound water itself manifested a unique hydrog...
A water strider demonstrates surface tension. Steve Maslowski/Getty Images The hydrogen bond between water molecules that we talked about in the first section is the reason behind two of water's unique properties: cohesion and adhesion. Cohesion refers to the fact that water sticks to itself ...
These molecules mediate an inflammatory response through cell activation to induce, for example, chemotaxis and histamine release. Rights and permissions Reprints and permissions About this article Cite this article Schwab, I., Nimmerjahn, F. Intravenous immunoglobulin therapy: how does IgG modulate the...
ATL cells express some cell surface molecules, such as c-c chemokine receptor type 4 (CCR4), a cluster of differentiation 25, 30, 52 (CD25, CD30, CD52), that are associated with the malignancy or tumorigenic behavior of the lymphocytes. CCR4 is a chemokine receptor type originally known ...
Remarkably, the increased RTK levels can also originate from reduced proteolytic shedding of cell surface receptors in MAPKi-treated cells [42]. The reduced levels of circulating RTKs can result in an accumulation of RTKs on the cell surface, which increases the flux through proliferation and ...
The reaction-limited kinetics of membrane-to-surface adhesion and detachment. Proc. R. Soc. Lond. B Biol. Sci. 234, 55–83 (1988). Article ADS CAS PubMed Google Scholar Marshall, B. T. et al. Direct observation of catch bonds involving cell-adhesion molecules. Nature 423, 190–193 ...
AlphaFold2 (AF2) provides a 3D structure for every known or predicted protein, opening up new prospects for virtually every field in structural biology. However, working with transmembrane protein molecules pose a notorious challenge for scientists, resu