that helps control these TEs. They’ve seen this pathway at work in certain cells that don’t age, like cancer stem cells, and notably, the enigmaticTurritopsis dohrnii, commonly known as the “immortal jellyfish.” By strengthening this pathway in a worm calledCaenorhabditis elegans, the worm...
When telomeres are too short, some cells turn into cancer. Cancerous cells have the ability to prevent their telomeres from getting shorter by activating telomerase. If telomerase makes cancer cells immortal, how would the administration of telomerase prevent normal cells from becoming cancero...
Another important way in which developing cancer cells can be stopped in their tracks is through the mechanism known asapoptosis, or programmed cell death. All normal body cells contain a genetic program that induces the cell to die under specific conditions. This is a vital means of removing d...
Cancer-associated fibroblasts (CAFs) are activated fibroblasts in the tumor microenvironment. They are one of the most prominent cell types in the stroma and produce large amounts of extracellular matrix molecules, chemokines, cytokines and growth factors. Importantly, CAFs promote cancer progression and...
Hence, PKM2 methylation is an important regulator of the switch between OXPHOS and aerobic glycolysis in cancer cells. PKM2 can also further promote the aerobic glycolysis process in tumor cells by affecting the PPP, which will be described later. Therefore, the specific mechanism and status of ...
While the body as a whole may be dead, little things within the body are still alive. Skin cells, for example, can be viably harvested for up to 24 hours after death [source: Mims]. But some things that are still alive lead to the putrefaction, or decomposition, of the body -- we...
: Specific association of human telomerase activity with immortal cells and cancer. Science 1994, 266:2011–2014. Article PubMed CAS Google Scholar Shay JW, Bacchetti S: A survey of telomerase activity in human cancer. Eur J Cancer 1997, 33:777–791. Article Google Scholar Wright WE, Pia...
From stem cells to cancer: balancing immortality and neoplasia In this issue of Oncogene, Serakinci et al show that adult stem cells can be targets for neoplastic transformation. After transducing human adult mesenchym... Keith,W Nicol - 《Oncogene》 被引量: 93发表: 2004年 ...
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Author of 'The Immortal Life of Henrietta Lacks' discusses the extraordinary ways medical research benefitted from an African American woman's cells—without her consent.