Addition of telomerase to extend cell division; Telomerase not made by most cells; Cells failing to show traits of cancer or form tumorlike colonies; Possibility that cells with telomerase may become malignant in humans; Concern that telomerase may not benefit all cell types.Ferber...
- 《International Journal of Cancer》 被引量: 220发表: 2004年 Prognostic relevance of Bmi-1 expression and autoantibodies in esophageal squamous cell carcinoma expression was higher in the immortalized cells, cancer cell lines and most cancer tissue than in non-tumorous control tissue at both mRNA...
Human colon cancer cells-Immortalized细胞,人肠癌细胞,永生化细胞,细胞纯度高,可实用性强,细胞活性高,STR鉴定,代次低,ATCC细胞库,中科院上海细胞库,传代细胞
This method is able to readily generate cancer stem cells that are low in the level of structural chromosomal aberrations and are excellent in oncogenicity, and is effectively applicable to the development of anti-cancer drugs and personalized drugs.Hong, Sunghoi...
human pancreatic cancer cells-Immortalized细胞,人胰腺癌细胞,永生化细胞,细胞纯度高,可实用性强,细胞活性高,STR鉴定,代次低,ATCC细胞库,中科院上海细胞库,传代细胞
In addition to the established role of human papillomaviruses (HPVs) in cervical cancer, smoking has been suggested to be an important cofactor. Previously, primary human ectocervical cells immortalized by HPV types 16 and 18 DNA did not form tumors on nude mice. Here, we derived a new line...
HaSKpw cells have one functional wild type p53 allele One characteristic for skin cancer cells are UV-dependent mutations of the p53 gene12,20. In line with these observations, HaCaT cells exhibit UV-indicative mutations in both alleles of the p53 gene and these mutations were present already ...
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Since Otto Warburg first hypothesized that the metabolic alterations observed in cancer cells had a causative impact on tumor development, the role of metabolism in cancer has been the focus of intense research and lively debate. Warburg's central observation was that tumor cells increase glucose upt...
The induction of HLA class II antigens on human thyroid epithelial cells has been shown to be an intimate part of the pathology of autoimmune thyroid disease and may also be relevant to the natural history of thyroid neoplasia since thyroid cancer cells may show spontaneous HLA class II antigen...