The invention relates generally to astrocyte cells comprising at least one DNA molecule capable of mediating cellular immortalization and/or transformation and comprising a factor capable of affecting metabolism, growth, differentiation, or survival of a brain cell. The present invention relates further ...
The immortalized cell lines induced by human papillomavirus type 16 (HPVS 16) YY1 binding-site mutants have some characteristics of transformed cells 来自 Semantic Scholar 喜欢 0 阅读量: 24 作者:H Liu,X Dong,W Zhou 摘要: OBJECTIVE: To study the biological characteristics of the immortalized ...
In the present study, we report that parabens can induce anchorage-independent growth of MCF-10A immortalized but non-transformed human breast epithelial cells, a property closely related to transformation and a predictor of tumour growth in vivo. In semi-solid methocel suspension culture, MCF-10A ...
1B). We examined anchorageindependent growth in soft agar dishes to determine whether the BEFS cell line was transformed. As shown in Fig. 1C, neither the BEFE nor the BEFS cells grew in the soft agar, suggesting that the latter had been immortalized but not transformed. Download: ...
We here present the spontaneously immortalised cell line, HaSKpw, as a novel model for the multistep process of skin carcinogenesis. HaSKpw cells were established from the epidermis of normal human adult skin that, without crisis, are now growing unrestr
3.3. PGC-1α KO iMEFs present a transformed phenotype To investigate the cellular basis for the higher oncogenic and pro-metastatic potential of PGC-1α KO iMEFs, we used a panel of in vitro assays to explore the different phenotypic characteristics typically associated with transformed cells. ...
Protein abundance for a given treatment at each day was normalized to the level of protein at day 0 under the same treatment condition and then log-transformed (yielding data on log2 fold change). Based on PCA (Fig. 4a), differences in the duration of differentiation projected primarily ...
The opposite effect of glucocorticoids on Bcl-2 levels in the two cell lines may be due to the different ontogeneses of the two cell types: epithelial for granulosa cells vs. mesenchymal for myeloid cells studied in the present work. 展开 ...
2.What are Immortalized Cells 3.What are Transformed Cells 4.Similarities Between Immortalized and Transformed Cells 5.Side by Side Comparison – Immortalized vs Transformed Cells in Tabular Form 6.Summary What are Immortalized Cells? Immortalized cells are the cells that have the ability to divide ...
The invention relates generally to astrocyte cells comprising at least one DNA molecule capable of mediating cellular immortalization and/or transformation and comprising a factor capable of affecting metabolism, growth, differentiation, or survival of a brain cell. The present invention relates further ...