Researchers show how toxic aggregates are formed inside brain cells, and how to block the cell-killing process—which may also be at work inAlzheimer’sand other neurodegenerative diseases. Prion diseases, such as Creutzfeldt-Jakob Disease (CJD), are fast-moving, fatal dementia syndromes associated...
and vinorelbine are widely used cytotoxic drugs that elicit their effects through disruption of microtubules, resulting in metaphase arrest in dividing cells [27]. Thus, these compounds would benefit from a controlled release dosage form that would result in a prolonged duration of exposure over exten...
Figure1: Left: cyst formed by MDCK cells expressing EB1-GFP(microtubules, green) embedded in Matrigel at day 17 of culture. It is presented as an extended depth of focus image with brightfield. Acquisition using the 63x/1.20 CS2 objective with widefocal and processed using THUNDER. Rig...
I. Force production by depolymerizing microtubules: a theoretical study. Proc. Natl Acad. Sci. USA 102, 4353–4358 (2005). Article ADS Google Scholar Matis, M. The mechanical role of microtubules in tissue remodeling. BioEssays 42, 1900244 (2020). Article Google Scholar Kozlov, M. M. ...
microtubulesvesicular transportGolgi apparatusendoplasmic reticulumMicrotubule array in eukaryotic cells supports directed transport of various cargoes driven by motor proteins. The arrangement of microtubules in cytoplasm is not stochastic; they are organized in a certain way setting a system of coordinates ...
关键词: CELL organelles -- Formation FLAGELLA (Microbiology MICROTUBULES DOI: 10.1083/jcb1553iti3 年份: 2001 收藏 引用 批量引用 报错 分享 全部来源 免费下载 求助全文 全文购买 Semantic Scholar Semantic Scholar (全网免费下载) NCBI (全网免费下载) NCBI Europe PMC 查看更多 ...
aIn cells, TACC3 is localized to both centrosomes and spindle microtubules, but is not found at astral microtubules once the spindle has formed. 在细胞,一旦纺锤形成了, TACC3地方化对两根中心体和纺锤微管,但没有被找到在星微管。[translate] ...
Compartmentalization and conservation may also be a function of the manchette since those elements which remain within the framework of microtubules are retained, while all the cytoplasm outside the manchette is discarded. At maturation, the endoplasmic reticulum plays a key role in dismantling the ...
Based on the physics of membrane bending, we quantitatively analyse the conditions under which membrane lipids could create the curvatures that characterize intracellular carriers, and conclude that the requirements for membrane lipid composition are stringent and unusual and that lipid-based mechanisms for...
The dynein complex is made up of several other proteins. The most important of these is a protein called dynactin1, which interacts with microtubules, enabling the dynein motor to move along microtubules. In the new study, the researchers found that dynactin1 is one of the major targets of ...