et al. Aub and Ago3 are recruited to nuage through two mechanisms to form a ping-pong complex assembled by krimper. Mol. Cell 59, 564–575 (2015). Article CAS PubMed PubMed Central Google Scholar Sundby, A. E., Molnar, R. I. & Claycomb, J. M. Connecting the dots: linking ...
Depolymerization is produced by conformational changes in GDP-tubulin since microtubules assembled with a slowly hydrolizable analog of GTP, GMPCPP, are stable even at 20 mM Mg2+ or 5 mM Ca2+. Monte Carlo simulations show that the ratio of the peeling to breakage rate constants can control the...
inclusion. Under these circumstances, the length of the paragraph can be up to 300 words. (The above example is 190 words without the final section, and 250 words with it). During cell division, mitotic spindles are assembled by microtubule-based motor proteins1, 2. The bipolar organization ...
In this clip, packages of one to four yellow fluorescence-labeled mRNAs with an intact localization signal travel on microtubules assembled in a micro-chamber which is mounted onto a microscope. Blue mRNAs have mutated localization signals which are not recognized by the transport machinery. ...
However, the precise roles of kinesin-5 during this process are unknown. Here we show that the vertebrate kinesin-5 Eg5 drives the sliding of microtubules depending on their relative orientation. We found in controlled in vitro assays that Eg5 has the remarkable capability of simultaneously ...
The viral particles are assembled within the infected plant cells when ribonucleoprotein complexes (RNPs) are enwrapped by Golgi cisternae. The Golgi membrane wrapped RNPs then fuse with each other and with ER membranes, producing a singly enveloped vesicle where virus par-...
Using monkey COS-7 cells as a model, the authors showed that blue irradiation triggered the translocation of peroxisomes from the cells' center to periphery, where most plus-microtubules are found. Furthermore, as the "cherry (not the fluorescent protein but the fruit of Cerasus spp...
Helical microtubules of graphitic carbon. Nature, 1991, 354(6348): 56−58. https://doi.org/10.1038/354056a0 Crossref Google Scholar [12] K.S. Novoselov, A.K. Geim, S.V. Morozov, et al. Electric field effect in atomically thin carbon films. Science, 2004, 306(5696): 666−...
Specifically, the protein annexin A11 acts as a tether that attaches RNA granules to the lysosomal membrane, thereby facilitating granule hitchhiking as lysosomes are transported on microtubules. These studies suggest an essential role of various endomembrane surfaces in regulating the positioning of ...
Paclitaxel is another cytotoxic chemotherapeutic drug that prevents depolymerization of microtubules by binding to tubulin and promoting its polymerization into microtubules, thereby inhibiting cell cycle progression [154]. Both PLD and paclitaxel are undergoing clinical trials separately and in combination. ...