Mechanistically, transcription factor HNF4A increased the expression of hexokinase 2 (HK2) and solute carrier family 2 member 1 (SLC2A1), while HNF4A-AS1 bound to heterogeneous nuclear ribonucleoprotein U (hnRNPU) to facilitate its interaction with CCCTC-binding factor (CTCF), resulting in ...
There are comments on PubPeer for publication: HNF4A-AS1/hnRNPU/CTCF axis as a therapeutic target for aerobic glycolysis and neuroblastoma progression (2020)
HumanHNF4AandMYCNexpression vectors were provided by Dr. David Martinez Selva [16] and Dr. Arturo Sala [17], respectively. HumanHNF4A-AS1cDNA (648 bp),hnRNPUcDNA (2478 bp),CTCFcDNA (2184 bp), and their truncations were amplified from NB tissues (Additional file 1: TableS2) and...