近日,武汉大学中南医院王行环教授团队在国际药物基因组学学会(the International Society of Pharmacogenomics,ISP)官方杂志The Pharmacogenomics Journal上发表了题为“Unveiling the association between HMG-CoA reductase inhibitors and bladder ...
英文名称:HMG-CoA Reductase 品牌厂商性质产地货期 MedChemExpress (MCE) 生产商 美国 现货 性能特点 HMG-CoA 还原酶 (HMGCR) 是 HMG-CoA 转化为甲羟戊酸过程中胆固醇合成的限速酶。 HMGCR 存在于真核生物和原核生物中。系统发育分析揭示了两类HMG-CoA还原酶,真核生 在线咨询 询底价 AI问答 配套的仪器设备...
Recombinant 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) HMG-CoA Reductase; Hydroxymethylglutaryl-CoA Reductase 来源:原核表达宿主:E.coli内毒素水平:<1.0EU/µg(LAL法测定)亚细胞定位:内质网腔预测分子量:30.0kDa实际分子量:30kDa(差异分析请参阅说明书)片段与标签:Ala638~Ala887 with N-terminal...
例句In conjunction with the glutathione reductase/peroxidase system, NADPH maintains the sulfhydryl groups of globin in their reduced state. NADPH通过与谷胱甘肽还原酶/过氧化物酶系统结合,维持球蛋白巯基基团的还原态。 概述 概述 HMG-CoA还原酶(3-羟基-3-甲基-戊二酰辅酶A还原酶,正式缩写为HMGCR,是速率...
HMG-CoA还原酶(HMGCR)是甲羟戊酸途径的速率控制酶,甲羟戊酸途径是产生胆固醇和其他类异戊二烯的代谢途径。通常在哺乳动物细胞中,这种酶被来自低密度脂蛋白(LDL)的内化和降解的胆固醇抑制,所述低密度脂蛋白通过LDL受体以及胆固醇的氧化物种。还原酶的竞争性抑制剂诱导
MCE 站:HMG-CoA Reductase 品牌:MedChemExpress (MCE) 概述:HMG-CoA 还原酶 (HMGCR) 是 HMG-CoA 转化为甲羟戊酸过程中胆固醇合成的限速酶。 HMGCR 存在于真核生物和原核生物中。系统发育分析揭示了两类HMG-CoA还原酶,真核生物和一些古细菌的I类酶以及真细菌和某些其他古细菌的II类酶。已知在真核生物和古细菌...
HMG-CoA Reductase (HMGCR) mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor as well as ...
AutophagyFerroptosisHMG-CoA Reductase ¥ 332 现货 规格 数量 客户已引用 SimvastatinMK-0733, 辛伐他汀, MK 733 T068779902-63-9 Simvastatin (MK 733) 是一种 HMG-CoA 还原酶抑制剂 (Ki=0.2 nM),具有口服活性。Simvastatin 具有降血脂活性,可以抑制肝脏产生胆固醇,还可以用于预防心血管疾病。
HMG-CoA reductase (HMGCR) is the rate-limiting enzyme for cholesterol biosynthesis. HMGCR is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from the product of the reductase reaction. Statin,a class of cholesterol-lowering drμgs inhibits HMGCR by...
HMG-CoA Reductase Inhibition of HMGCR activity results in decreased levels of mevalonate and its downstream products that affect critical cell functions such as membrane integrity, cell signaling, protein synthesis, and cell cycle progression (Hindler et al., 2006)....